A Preliminary Trial to Determine Whether Prevention of Dark Adaptation Affects the Course of Early Diabetic Retinopathy

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dc.contributor.authorArden, G. B.
dc.contributor.authorGündüz, M. K.
dc.contributor.authorKurtenbach, A.
dc.contributor.authorVölker, M.
dc.contributor.authorZrenner, E.
dc.contributor.authorGündüz, S. B.
dc.contributor.authorKamis, Ü.
dc.contributor.authorÖztürk, B. T.
dc.contributor.authorOkudan, S.
dc.date.accessioned2020-03-26T17:46:46Z
dc.date.available2020-03-26T17:46:46Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was designed to determine whether a new form of treatment of diabetic retinopathy (DR) was acceptable to patients and whether reduction in the maximal activity of rods in diabetes could affect the progress of DR. Methods In 12 patients, trans-lid retinal illumination of one eye was employed during sleep to prevent the depolarisation of rods and thus reduce their metabolic activity. Techniques A headband was used to place a source of chemical light over one eye, with its fellow as a control. Measurements Colour contrast thresholds were measured before and after a period of treatment in treated eyes, and the changes were compared to those in untreated fellow eyes, and areas of 'dark retinal anomalies' (microaneurysms, dot haemorrhages) were measured at the same time points. Results Patients found this intervention to be acceptable, and no adverse effects were noted. In the majority of cases, and for each outcome measure, the treated eyes improved relative to their fellows. The intervention significantly reduced the tritan thresholds in treated eyes relative to their fellows (P = 0.03), and the area of dark retinal anomalies decreased in treated eyes and increased in untreated eyes, with a similar probability. Conclusions The study showed that this intervention is safe. Although the study was not powered to study efficiacy, the results are promising and consistent with other reports that indicate the retina in DR is suffering from hypoxia; however, further trials should be undertaken.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [05401095]en_US
dc.description.sponsorshipThis work was supported in part by a grant from Selcuk University Scientific Research Projects Funds (project no. 05401095) and has previously been communicated in part to the Selcuk University/Konya and to Yuksek Ogretim Kurumu/Ankara. Some results have been presented at the 47th symposium of ISCEV, 2009. We acknowledge the gift of modified glowpatches by Omniglow Corporation, which made the project possible. We thank Dr I White, Department of Mathematics, Imperial College London, for statistical advice and Miss S Sivaprasad for critical reading of the paper.en_US
dc.identifier.citationArden, G. B., Gündüz, M. K., Kurtenbach, A., Völker, M., Zrenner, E., Gündüz, S. B., Kamis, Ü., Öztürk, B. T., Okudan, S., (2010). A Preliminary Trial to Determine Whether Prevention of Dark Adaptation Affects the Course of Early Diabetic Retinopathy. Eye, (24), 1149-1155. Doi: 10.1038/eye.2009.328
dc.identifier.doi10.1038/eye.2009.328en_US
dc.identifier.endpage1155en_US
dc.identifier.issn0950-222Xen_US
dc.identifier.pmid20139913en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1149en_US
dc.identifier.urihttps://dx.doi.org/10.1038/eye.2009.328
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24540
dc.identifier.volume24en_US
dc.identifier.wosWOS:000279976000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGündüz, M. K.
dc.institutionauthorKamis, Ü.
dc.institutionauthorÖztürk, B. T.
dc.institutionauthorOkudan, S.
dc.institutionauthorGündüz, S. B.
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofEyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectDark-adaptationen_US
dc.subjectPhotoreceptoren_US
dc.subjectDark currenten_US
dc.subjectColour visionen_US
dc.subjectMicroaneurysmsen_US
dc.titleA Preliminary Trial to Determine Whether Prevention of Dark Adaptation Affects the Course of Early Diabetic Retinopathyen_US
dc.typeArticleen_US

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