Fibrinolytic markers and neurologic outcome in traumatic brain injury

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dc.contributor.authorBayir, Aysegul
dc.contributor.authorKalkan, Erdal
dc.contributor.authorKocak, Sedat
dc.contributor.authorAk, Ahmet
dc.contributor.authorCander, Basar
dc.contributor.authorBodur, Said
dc.date.accessioned2020-03-26T17:03:34Z
dc.date.available2020-03-26T17:03:34Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAims: To determine the usefulness of fibrinolytic markers as early prognostic indicators in patients with isolated head trauma. Materials and Methods: Sixty-two consecutive patients (26 women and 36 men; mean age 61 years, range 2-76 years) with isolated head trauma seen within the first three hours of the trauma were included in the study. The Glasgow Coma score (GCS), platelet counts (Plt), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, fibrin degradation products (FDP) and D-dimer levels were measured. Head computerized tomography (CT) findings were categorized as brain edema, linear fracture, depressed fracture, contusion and bleeding. Plt counts, PT, PTT, fibrinogen, FDP, D-dimer levels and CT findings were compared with both GCS and mortality in the first week. Statistical significance was accepted at P <= 0.05. Results: A marked negative relationship was found between GCS and PT, PTT, FDP and D-climer levels (P < 0.001). Plt levels did not correlate with GCS. Mortality was most strongly related to GCS, PT, FDP and D-dimer levels (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). We found no relationship between mortality and CT findings, nor was there any significant relationship between Plt, PTT and fibrinogen levels. Conclusion: GCS and fibrinolytic markers measured within the first three hours were useful in determining the prognosis of patients with isolated head trauma.en_US
dc.identifier.doi10.4103/0028-3886.28106en_US
dc.identifier.endpage365en_US
dc.identifier.issn0028-3886en_US
dc.identifier.issue4en_US
dc.identifier.pmid17114843en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0028-3886.28106
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20496
dc.identifier.volume54en_US
dc.identifier.wosWOS:000242413000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNEUROL SOC INDIAen_US
dc.relation.ispartofNEUROLOGY INDIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdisseminated intravascular coagulopathyen_US
dc.subjectfibrinogenen_US
dc.subjectGlasgow Coma scoreen_US
dc.subjectprognosisen_US
dc.subjecttraumatic brain injuryen_US
dc.titleFibrinolytic markers and neurologic outcome in traumatic brain injuryen_US
dc.typeArticleen_US

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