Preoperative neutrophil-to-lymphocyte ratio (NLR) may be predictive of pathologic stage in patients with bladder cancer larger than 3 cm

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dc.contributor.authorCelik, O.
dc.contributor.authorAkand, M.
dc.contributor.authorKeskin, M. Z.
dc.contributor.authorYoldas, M.
dc.contributor.authorIlbey, Y. O.
dc.date.accessioned2020-03-26T19:25:44Z
dc.date.available2020-03-26T19:25:44Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Bladder cancer (BCa) is the most common malignancy of the urinary tract. In this study, we aimed to evaluate the ability of preoperative neutrophil-to-lymphocyte ratio (NLR) to predict pathologic stage of at the time of first transurethral resection of bladder tumor (TUR-BT) in patients with BCa larger than 3 cm. PATIENTS AND METHODS: Records of consecutive patients undergoing TUR-BT for BCa with a diameter >3 cm were reviewed. A total of 222 patients were eligible for analysis, and were divided into two groups: 162 patients in non-muscle-invasive BCa (NMIBC) group and 60 patients in muscle-invasive BCa (MIBC) group. Differences in preoperative blood parameters and NLR were evaluated between groups with an unequal variance t-test. RESULTS: In the NMIBC group, 59 patients had low-grade and 103 high-grade papillary urothelial carcinomas. 60 patients had T2 stage carcinoma. The mean age of the patients was 71.8 and 75.7 years, and mean NLR was 3.44 +/- 2.03 and 4.6 +/- 2.8 in NMIBC and MIBC groups, respectively. In terms of NLR, there was a statistically significant difference between the NMIBC and MIBC groups (p = 0.005). CONCLUSIONS: Our results showed that NLR might act as a significant predictive biomarker on the staging of BCa. Also, NLR could be used as a cost-effective, simple, common usable biomarker in urology clinic practice.en_US
dc.identifier.endpage656en_US
dc.identifier.issn1128-3602en_US
dc.identifier.issue4en_US
dc.identifier.pmid26957266en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage652en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33897
dc.identifier.volume20en_US
dc.identifier.wosWOS:000373349200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERDUCI PUBLISHERen_US
dc.relation.ispartofEUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBladder canceren_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyteen_US
dc.subjectMuscle-invasiveen_US
dc.subjectStageen_US
dc.titlePreoperative neutrophil-to-lymphocyte ratio (NLR) may be predictive of pathologic stage in patients with bladder cancer larger than 3 cmen_US
dc.typeArticleen_US

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