Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams

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dc.contributor.authorAtaman, Mehmet Bozkurt
dc.contributor.authorDonmez, Hasan Huseyin
dc.contributor.authorDoenmez, Nurcan
dc.contributor.authorSur, Emrah
dc.contributor.authorBucak, Mustafa Numan
dc.contributor.authorCoyan, Kenan
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of aflatoxin (AF) on spermatologic, biochemical, and testis parameters in rams, and the protective efficiency of esterified glucomannan (EG) co-administered with AF. Thirty-two Merino rams (12-14 months old) were used. The experimental design consisted of four dietary treatments. The control group was fed commercial feed. The AF group was fed with commercial feed plus 250 mu g/d of total AF. The EG group received commercial feed plus 2 g/d of EG. The AF + EG group was given commercial feed plus 250 mu g/d of total AF and 2 g/d of EG. There were treatment, time, and treatment-by-time interaction effects on sperm motility, abnormal spermatozoa, damaged acrosome, and dead spermatozoa (P < 0.01). The percentage of motile sperm was lower and the percentages of abnormal sperm, sperm with damaged acrosomes, and dead sperm were greater in the AF group than in the control, AF+EG, and EG groups, as from week 3 until the end of week 12 (P < 0.05). As from week 3, hyaluronidase activity in the seminal plasma increased significantly in the AF group, compared with the control. The co-administration of AF+EG was found to be effective in preventing the increase in hyaluronidase activity. As week 4, malondialdehyde (MDA) levels were significantly higher in the AF group compared with the control. The combined administration of AF+EG was found to be effective in lowering the MDA levels, increased by AF, to the levels measured in the control (P < 0.05). Although glutathione (GSH) levels were determined to have significantly decreased in the AF group in comparison to the control, it was observed that, in the group co-administered with AF and EG, particularly after week 7, the GSH levels, which had decreased owing to AF, were largely ameliorated (P < 0.05). In conclusion, AF adversely affected spermatologic, biochemical, and testis parameters, and the combined administration of EG with AF reversibly eliminated these adverse effects in rams. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107 O 866]en_US
dc.description.sponsorshipThis study is dedicated to my beloved mother, Emel Aynur Ataman, who passed away after cancer treatment. This study was financed under a project supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 107 O 866).en_US
dc.identifier.doi10.1016/j.theriogenology.2013.10.007en_US
dc.identifier.endpage380en_US
dc.identifier.issn0093-691Xen_US
dc.identifier.issn1879-3231en_US
dc.identifier.issue3en_US
dc.identifier.pmid24210915en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.theriogenology.2013.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31094
dc.identifier.volume81en_US
dc.identifier.wosWOS:000330254400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofTHERIOGENOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRamen_US
dc.subjectAflatoxinen_US
dc.subjectGlucomannanen_US
dc.subjectReproductive parametersen_US
dc.titleProtective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in ramsen_US
dc.typeArticleen_US

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