Effect of Cooling on the Responses of Human Saphenous Vein to Fentanyl, Remifentanil and Sufentanil

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dc.contributor.authorŞahin, Ayşe Saide
dc.contributor.authorDuman, Ateş
dc.contributor.authorGünaydın, İshak Gürsel
dc.contributor.authorŞahin, Tahir Kemal
dc.contributor.authorGörmüş, Niyazi
dc.contributor.authorDuman, İpek
dc.date.accessioned2020-03-26T17:03:23Z
dc.date.available2020-03-26T17:03:23Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe studied the vasodilatory effects of fentanyl, remifentanil and sufentanil on the human saphenous vein strips at 37, 32 and 28 degrees C. Fentanyl produced concentration-dependent relaxation of human saphenous vein strips precontracted with 5-hydroxytryptamine (5-HT) at every temperature studied. Compared with vein strips at 37 degrees C, relaxant responses to each one concentration of fentanyl were significantly reduced at 32 and 28 degrees C. Remifentanil relaxed vein strips in a concentration-dependent way and the relaxation for all concentrations were significantly greater at 32 and 28 degrees C compared with 37 degrees C. Sufentanil produced concentration-dependent relaxation in saphenous vein strips precontracted with 5-HT. These relaxant responses were similar at 32 degrees C compared with 37 degrees C. When bath temperature was lowered from 37 to 28 degrees C, the relaxant responses to sufentanil were significantly reduced. In summary, the present study suggests that cooling reduces the relaxation caused by fentanyl and sufentanil on human saphenous veins but augments the relaxation with remifentanil. The augmented vasodilatory effect of remifentanil with cooling may be useful on systemic vascular resistance and organ preservation under hypothermic conditions like cardiopulmonary bypass surgery.en_US
dc.identifier.citationŞahin, A. S., Duman, A., Günaydın, İ. G., Şahin, T. K., Görmüş, N., Duman, İ., (2000). Effect of Cooling on the Responses of Human Saphenous Vein to Fentanyl, Remifentanil and Sufentanil. Fundamental & Clinical Pharmacology, 20(5), 473-476. Doi: 10.1111/j.1472-8206.2006.00434.x
dc.identifier.doi10.1111/j.1472-8206.2006.00434.xen_US
dc.identifier.endpage476en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issue5en_US
dc.identifier.pmid16968417en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2006.00434.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20441
dc.identifier.volume20en_US
dc.identifier.wosWOS:000240493500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞahin, Ayşe Saide
dc.institutionauthorDuman, Ateş
dc.institutionauthorGünaydın, İshak Gürsel
dc.institutionauthorŞahin, Tahir Kemal
dc.institutionauthorGörmüş, Niyazi
dc.institutionauthorDuman, İpek
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoolingen_US
dc.subjectfentanylen_US
dc.subjecthuman saphenous veinen_US
dc.subjectremifentanilen_US
dc.subjectsufentanilen_US
dc.titleEffect of Cooling on the Responses of Human Saphenous Vein to Fentanyl, Remifentanil and Sufentanilen_US
dc.typeArticleen_US

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