Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats

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dc.contributor.authorKoç, Aynur
dc.contributor.authorErgene, Neyhan
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMogulkoc, Rasim
dc.date.accessioned2020-03-26T20:19:52Z
dc.date.available2020-03-26T20:19:52Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study aimed to examine the affects of 3’-4’-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats. © 2019 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.en_US
dc.description.sponsorshipNational Council for Scientific Research: NEU-BAP-131318001en_US
dc.description.sponsorshipThis study was supported by a grant Necmettin Erbakan University, Scientific Research Council (Grant number is NEU-BAP-131318001). The authors declare that there are no conflicts of interest.en_US
dc.identifier.citationKoç, A., Ergene, N., Baltacı, A.K., Mogulkoc, R. (2019). Effect of 3’-4’-Dihydroxyflavonol on Lipid Per Oxidation in Experimental Renal Ischemia-Reperfusion in Rats. Pakistan Journal of Pharmaceutical Sciences, 32,(6), 2579-2584.
dc.identifier.doi10.36721/PJPS.2019.32.6.REG.2579-2584.1en_US
dc.identifier.endpage2584en_US
dc.identifier.issn1011601Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid31969289en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2579en_US
dc.identifier.urihttps://dx.doi.org/10.36721/PJPS.2019.32.6.REG.2579-2584.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38427
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltacı, Abdülkerim Kasım
dc.institutionauthorMogulkoc, Rasim
dc.language.isoenen_US
dc.publisherPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject3’-4’-Dihydroxyflavonolen_US
dc.subjectLipid per oxidationen_US
dc.subjectRaten_US
dc.subjectRenal ischemia-reperfusionen_US
dc.titleEffect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in ratsen_US
dc.typeArticleen_US

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