Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer

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dc.contributor.authorAltıntaş, Emre
dc.contributor.authorKaynar, Mehmet
dc.contributor.authorÇelik, Zehra Esin
dc.contributor.authorÇelik, Murat
dc.contributor.authorKılıç, Özcan
dc.contributor.authorAkand, Murat
dc.contributor.authorGöktaş, Serdar
dc.date.accessioned2020-03-26T20:20:16Z
dc.date.available2020-03-26T20:20:16Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To determine the relationship between RING-box protein 1 (RBX-1) expression and renal cell carcinoma (RCC) with prognostic factors. Methods: A total of 88 patients who underwent radical/partial nephrectomy between January 2009 and January 2016 have been included in our study. The age, gender, tumor location, tumor size, and tumor-node-metastasis stage of each patient was evaluated. From the best sections in hematoxylin-eosin stained pathology preparations, tumor histological subtype, Fuhrman nuclear grade, lymphovascular invasion, renal artery/vein invasion, capsule invasion, perirenal fatty tissue invasion, and tumor grade were evaluated. Participants were divided into 2 groups according to Fuhrman grade. Fuhrman grades 1 to 2 comprised Group 1, and Fuhrman grades 3 to 4 comprised Group 2. An immunoreactivity scoring system was used to evaluate RBX-1 expression. Results: Upon examining all histological subtypes together, it was observed that RBX-1 expression was statistically higher in Group 2 compared to Group 1 (P < 0.008). Upon examining clear RCC cases, it was observed again that Group 2 had a higher RBX-1 expression than Group 1 (P < 0.009). RBX-1 expression was not associated with clinical-pathological parameters including tumor grade, lymphovascular invasion, capsule invasion, or perirenal invasion. Conclusion: RBX-1 expression is closely associated with a highly important prognostic factor in RCC-Fuhrman grade-and it shows promise as a prognostic marker. Further studies are required to reveal the importance of RBX-1 in RCC prognosis and treatment. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationAltintas, E., Kaynar, M., Celik, Z. E., Celik, M., Kilic, O., Akand, M., Goktas, S. (2020). Expression of Ring Box-1 Protein and Its Relationship with Fuhrman Grade and Other Clinical-Pathological Parameters in Renal Cell Cancer. Urologic Oncology: Seminars and Original Investigations, 38(1), 6e17-6e22.
dc.identifier.doi10.1016/j.urolonc.2019.09.019en_US
dc.identifier.issn1078-1439en_US
dc.identifier.issn1873-2496en_US
dc.identifier.issue1en_US
dc.identifier.pmid31653562en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.urolonc.2019.09.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38546
dc.identifier.volume38en_US
dc.identifier.wosWOS:000499961100016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaynar, Mehmet.
dc.institutionauthorCelik, Z. Esin.
dc.institutionauthorKilic, Ozcan.
dc.institutionauthorAkand, Murat.
dc.institutionauthorGoktas, Serdar.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofUROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRenal cell canceren_US
dc.subjectRing box protein-1en_US
dc.subjectFuhrman grading systemen_US
dc.subjectImmunohistochemistryen_US
dc.titleExpression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell canceren_US
dc.typeArticleen_US

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