Bacterial translocation and intestinal injury in experimental necrotizing enterocolitis model

Basit Öğe Kaydı
dc.contributor.authorÇiftçi, İlhan
dc.contributor.authorÖzdemir, Mehmet
dc.contributor.authorAktan, Tahsin Murad
dc.contributor.authorAsian, K.
dc.date.accessioned2020-03-26T18:24:05Z
dc.date.available2020-03-26T18:24:05Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To study the occurrence of bacterial translocation and to assess the impact of breasffeeding on bacterial translocation in the animal model of necrotizing enterocolitis. Methods: A total of 20 neonate Sprague-Dawley rats were enrolled in the study. Rats were randomly allocated into either control or study group just after birth. Ten newborn rats in the control group were left with their mother to be breast-fed. In contrary, necrotizing enterocolitis group consisted of neonates that were separated from their mothers, housed in an incubator and were gavaged with a special rodent formula three times daily. Survival rates, weight changes, and morphologic scoring obtained after microscopic evaluation were determined as microbiologic evaluation criteria. Results: All the rats in the control group survived, while 1 (10 %) rat died in the necrotizing enterocolitis group. Mortality rates of the two groups were similar. All the formula-fed animals in the necrotizing enterocolitis group had significant weight loss compared to the breast milk-fed rats in the control group (p<0.05). A total of 7 (70 %) and 2 (20 %) E. coli growths were identified in the bowel lumen, liver, and spleen of necrotizing enterocolitis and control groups, respectively. This difference was statistically significant. In peritoneal smear cultures, a total of 3 (30 %) growths were detected in the necrotizing enterocolitis group and 1 (10 %) growth in the control group. Conclusion: As the result of a disturbance in the intestinal flora and impairment of the intestinal barrier in necrotizing enterocolitis, microrganisms in the bowel pass through the intestinal barrier and reach the liver and the spleen via the hematogenous route. This condition is closely related to the impairment of physiological and functional features of the intestinal barrier and is independent from the degree of intestinal injury. Bacterial translocation should be remembered in cases suspected of necrotizing enterocolitis, and a rapid and effective treatment algorithm should be applied in such circumstances (Tab. 3, Fig. 3, Ref. 21). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_047en_US
dc.identifier.endpage210en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue4en_US
dc.identifier.pmid22502749en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2012_047
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27783
dc.identifier.volume113en_US
dc.identifier.wosWOS:000303372800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnecrotizing enterocolitisen_US
dc.subjectbacteriaen_US
dc.subjecttranslocationen_US
dc.subjectepithelial barrieren_US
dc.subjectmucosaen_US
dc.subjectmaternal milk feedingsen_US
dc.titleBacterial translocation and intestinal injury in experimental necrotizing enterocolitis modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu