Antiangiogenic Effect of Itraconazole on Corneal Neovascularization: A pilot Experimental Investigation

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dc.contributor.authorGoktas, Sertan
dc.contributor.authorSakarya, Rabia
dc.contributor.authorErdogan, Ender
dc.contributor.authorSakarya, Yasar
dc.contributor.authorOzcimen, Muammer
dc.contributor.authorDursunoglu, Duygu
dc.contributor.authorKocacan, Metin
dc.date.accessioned2020-03-26T18:49:24Z
dc.date.available2020-03-26T18:49:24Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. Materials and Methods: Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauterization of the cornea was performed using silver nitrate/potassium nitrate sticks, and the rats were subsequently treated daily with topical (10 mg/ml), subconjunctival (10 mg/ml) or intraperitoneal (19 mg/kg) itraconazole for 7 days. Control rats received topical, subconjunctival or intraperitoneal 0.9% saline. On the 8th day of the experiment, the rat corneas were photographed to determine the percentage area of the cornea covered by neovascularization. The maximum density of corneal neovascularization was determined by microscopy. Results:The median percentage of corneal neovascularization for group 1 was 31.5% (95% confidence interval, 27.5-35.5%); in group 3, it was 32% (23.5-39.8%); in group 5, it was 47% (36.3-60.0%). The percentages of corneal neovascularization in groups 2, 4 and 6 (the control groups) were 70% (95% confidence interval, 60.7-77.3%), 69% (63.0-77.7%) and 68% (56.5-78.5%), respectively. The area of neovascularization was smaller after itraconazole treatment as compared to saline treatment. Further, the area of neovascularization was smaller after topical and subconjunctival administration than after intraperitoneal administration. Histological evaluation of the corneas showed the most extensive corneal neovascularization in the control group. No local or systemic adverse effects were seen from either treatment group. Conclusion: ltraconazole reduces corneal neovascularization shortly after chemical burn. However, a larger experimental study is necessary to confirm the data of this investigation. (C) 2014 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000366283en_US
dc.identifier.endpage174en_US
dc.identifier.issn0030-3747en_US
dc.identifier.issn1423-0259en_US
dc.identifier.issue4en_US
dc.identifier.pmid25342430en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000366283
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30601
dc.identifier.volume52en_US
dc.identifier.wosWOS:000345675200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOPHTHALMIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCorneaen_US
dc.subjectNeovascularizationen_US
dc.subjectChemical burnen_US
dc.subjectItraconazoleen_US
dc.titleAntiangiogenic Effect of Itraconazole on Corneal Neovascularization: A pilot Experimental Investigationen_US
dc.typeArticleen_US

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