Immunohistochemical and morphometric evaluation of neuronal dysfunction in pelviureteral junction obstruction

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dc.contributor.authorGündüz, Metin
dc.contributor.authorYurtçu, Müslim
dc.contributor.authorToy, Hatice
dc.contributor.authorAbasıyanık, Adnan
dc.contributor.authorDemirci, Şerafettin
dc.date.accessioned2020-03-26T18:42:08Z
dc.date.available2020-03-26T18:42:08Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: The pathophysiology of pelviureteral junction obstruction remains unclear. In this study, we attempted to evaluate the neuronal dysfunction using immunohistochemical and morphometric parameters. Materials and methods: Using specific antibodies, we studied the neuronal markers and morphometry of specimens from 10 cases of pelviureteral junction obstruction and 10 normal pelviureteral junctions by immunohistochemistry using synaptophysin (synaptic vesicle membrane protein), S-100 (nerve cell fiber marker), protein gene product 9.5 (neuron specific protein) and CD-117 (transmembrane receptor with tyrosine kinase activity). Results: In pelviureteral junction obstruction, smooth muscle thickness was significantly higher than in normal specimens. Cytoplasmic cells stained by synaptophysin were found in the pelviureteral junction obstruction specimens but were absent in normal pelviureteral junction specimens. In addition, significantly more intense staining for S-100 was found in the pelviureteral junction obstruction specimens compared with the normal specimens. Immunohistochemical staining for protein gene product 9.5 showed no differences between the normal and pelviureteral junction obstruction specimens. Neither the normal specimens nor pelviureteral junction obstruction groups were stained by CD-117. Conclusion: We propose that the cause of neuronal dysfunction in pelviureteral junction obstruction depends on the increase in number and structure of neuronal cells and smooth muscle thickness. These factors could play an important role in the pathophysiology of pelviureteral junction obstruction by affecting motility and peristalsis. (C) 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research ProjectsSelcuk University [2007/69]en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination number: 2007/69 date 24/09/2007.en_US
dc.identifier.doi10.1016/j.jpurol.2012.05.003en_US
dc.identifier.endpage363en_US
dc.identifier.issn1477-5131en_US
dc.identifier.issue3en_US
dc.identifier.pmid22682546en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpurol.2012.05.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29560
dc.identifier.volume9en_US
dc.identifier.wosWOS:000319498000030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC UROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNeuronal dysfunctionen_US
dc.subjectPelviureteral junctionen_US
dc.titleImmunohistochemical and morphometric evaluation of neuronal dysfunction in pelviureteral junction obstructionen_US
dc.typeArticleen_US

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