Assessment of the New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: A Prospective Multicenter Study

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dc.contributor.authorOzen, Gulsen
dc.contributor.authorInanc, Nevsun
dc.contributor.authorUnal, Ali Ugur
dc.contributor.authorBas, Seda
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorKisacik, Bunyamin
dc.contributor.authorOnat, Ahmet Mesut
dc.date.accessioned2020-03-26T19:23:09Z
dc.date.available2020-03-26T19:23:09Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective. To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/ American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study. Methods. Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR. At the end of the 1-year followup, 133 patients were diagnosed with PMR (expert opinion) and 142 with non-PMR conditions [69 rheumatoid arthritis (RA)]. Discriminating capacity, sensitivity, and specificity of the criteria sets were estimated. Results. Discriminating capacity of the new clinical criteria for PMR from non-PMR conditions and RA as estimated by area under the curve (AUC) were good with AUC of 0.736 and 0.781, respectively. The new criteria had a sensitivity of 89.5% and a specificity of 57.7% when tested against all non-PMR cases. When tested against all RA, seropositive RA, seronegative RA, and non-RA control patients, specificity changed to 66.7%, 100%, 20.7%, and 49.3%, respectively. Except for the Bird criteria, the 4 previous criteria had lower sensitivity and higher specificity (ranging from 83%-93%) compared with the new clinical criteria in discriminating PMR from all other controls. Conclusion. The new 2012 EULAR/ ACR clinical classification criteria for PMR is highly sensitive; however, its ability to discriminate PMR from other inflammatory/noninflammatory shoulder conditions, especially from seronegative RA, is not adequate. Imaging and other modifications such as cutoff values for APR might increase the specificity of the criteria.en_US
dc.identifier.doi10.3899/jrheum.151103en_US
dc.identifier.endpage900en_US
dc.identifier.issn0315-162Xen_US
dc.identifier.issn1499-2752en_US
dc.identifier.issue5en_US
dc.identifier.pmid26834222en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage893en_US
dc.identifier.urihttps://dx.doi.org/10.3899/jrheum.151103
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33288
dc.identifier.volume43en_US
dc.identifier.wosWOS:000380854200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ RHEUMATOL PUBL COen_US
dc.relation.ispartofJOURNAL OF RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPOLYMYALGIA RHEUMATICAen_US
dc.subjectCLASSIFICATION CRITERIAen_US
dc.subjectRHEUMATOID ARTHRITISen_US
dc.titleAssessment of the New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: A Prospective Multicenter Studyen_US
dc.typeArticleen_US

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