Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion

Basit Öğe Kaydı
dc.contributor.authorYurtçu, Müslim
dc.contributor.authorAbasıyanık, Adnan
dc.contributor.authorBiçer, Şenol
dc.contributor.authorAvınduk, Mustafa Cihat
dc.date.accessioned2020-03-26T17:38:31Z
dc.date.available2020-03-26T17:38:31Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/Purpose: This study aimed to compare dose schedules of the antioxidant treatment (melatonin and steroid) used as I dose and as once a day for 7 days in terms of salvage of the testes in the late period. Methods: Sixty prepubertal rats were divided into 6 groups each containing 10 rats: sham (S), torsion-detorsion (TD), 1-dose melatonin (M-1), 1-dose steroid (ST1), 7-dose melatonin (M-7), and 7-dose steroid (ST7) groups. The left testes were rotated 720 degrees for 6 hours and detorsed for 6 hours thereafter. In the treatment groups, 17 mg/kg melatonin and I mg/kg steroid were injected 15 minutes before detorsion. Left orchiectomies were performed to determine testicular weights and Johnsen scores 3 months later. Results: Testicular weights and Johnsen scores in the M-1, ST1, and TD groups were significantly lower compared with those in the S group, and atrophy developed in these groups, whereas they were higher in the M-7 and ST7 groups compared with the TD group. Testicular atrophy did not develop in the M-7 or ST7 groups. Conclusions: Our results suggested that antioxidant agents used once a day for 7 days prevent testicular atrophy and are effective in terms of salvage of the testes. (c) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2008.11.043en_US
dc.identifier.endpage1758en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issn1531-5037en_US
dc.identifier.issue9en_US
dc.identifier.pmid19735821en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1754en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpedsurg.2008.11.043
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23502
dc.identifier.volume44en_US
dc.identifier.wosWOS:000270065100021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTesticular torsionen_US
dc.subjectIschemia-reperfusion damageen_US
dc.subjectMelatoninen_US
dc.subjectSteroiden_US
dc.titleEfficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsionen_US
dc.typeArticleen_US

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