Pinealectomy inhibits antioxidant system in rats with hyperthyroidism

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dc.contributor.authorMogulkoc, R
dc.contributor.authorBaltaci, AK
dc.contributor.authorAydin, L
dc.contributor.authorOztekin, E
dc.contributor.authorSivrikaya, A
dc.date.accessioned2020-03-26T16:57:43Z
dc.date.available2020-03-26T16:57:43Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Thyroid hormones regulate energy metabolism and act on the mitochondria, which is an important source of free radicals in the cell. Reactive oxygen types play a significant role in physiological mechanisms, but in excessive amounts they can cause oxidative damage in molecules. The aim of the present study was to determine levels of lipid peroxidation caused by induced hyperthyroidism in cerebral, hepatic and cardiac tissues of pinealectomized rats. METHODS: Experimental animals used in the study were allocated to three groups as general control group, hyperthyroidism-sham pinealectomy group and hyperthyroidism-pinealectomy group. GSH and MDA levels in cerebral, hepatic and cardiac tissues were evaluated at the end of the 3-week study period. RESULTS: It was found that MDA levels in cerebral, hepatic and cardiac tissues were the highest in hyperthyroidism and pinealectomy group and that these values were higher in hyperthyroidism-sham pinealectomy group than in the control group (p < 0.001). it was seen that tissue GSH levels significantly increased in hyperthyroidism-sham pinealectomy group (p < 0.001) and that the increase in hyperthyroidism and pinealectomy group was higher than the increase in the control group only (p < 0.001). CONCLUSION: Results of our study show that MDA and GSH levels in cerebral, hepatic and cardiac tissues increased due to hyperthyroidism and that the increase in MDA levels became more evident and GSH levels were significantly suppressed after pinealectomy.en_US
dc.identifier.endpage798en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid16380688en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage795en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19836
dc.identifier.volume26en_US
dc.identifier.wosWOS:000236048900034en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjectpinealectomyen_US
dc.subjectbrainen_US
dc.subjectliveren_US
dc.subjecthearten_US
dc.subjectraten_US
dc.titlePinealectomy inhibits antioxidant system in rats with hyperthyroidismen_US
dc.typeArticleen_US

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