Asphodeline Cilicica Tuzlaci: From the Plant to Its Most Active Part Extract and Its Broad Bioactive Properties
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study investigated into the polyphenolic content, antioxidant and enzyme (a-amylase, a-glucosidase, tyrosinase, acetylcholinesterase [AChE], and butyrylcholinesterase [BChE]) inhibitory activities of 12 extracts of the endemic Asphodeline cilicica (AC) Tuzlaci, from Turkey. The total phenolic content for the methanol and acetone extracts of AC roots were 56.52 and 52.96 mg GAEs/g extract, respectively. Both the acetone and methanol extracts of AC roots exhibited an important antioxidant capacity. Likewise, the acetone and methanol extracts of AC roots revealed to be the most potent scavengers of DPPH radical (58.25 and 58.78 mg TEs/g extract). Acetone extract of AC roots inhibited a-amylase showing an acarbose equivalent value (mmol ACAEs/g extract) of 0.27, while against a-glucosidase the value recorded was 2.30. The acetone and methanol extracts of the different plant parts of AC inhibited AChE and BChE, while no/poor activity was noted for the water extracts. In the present study, extracts of AC showed inhibitory activity against key enzymes involved in diabetes and neurodegenerative complications, thereby advocating for the need for in-depth studies geared towards the discovery of pharmacophores from this endemic plant. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Asphodeline cilicica Tuzlaci, Antioxidant, Flavonoids, Natural enzyme inhibitors, Turkey, Antioksidan, Flavonoidler, Doğal enzim inhibitörleri
Kaynak
South African Journal of Botany
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
120
Sayı
Künye
Zengin, G., Aktümsek, A., Mocan, A., Rengasamy, K. R. R., Picot, C. M. N., Mahomoodally, M. F. (2019). Asphodeline cilicica Tuzlaci: From the plant to its most active part extract and its broad bioactive properties. South African Journal of Botany, 120, 186-190. doi: https://dx.doi.org/10.1016/j.sajb.2018.05.014
