Asphodeline Cilicica Tuzlaci: From the Plant to Its Most Active Part Extract and Its Broad Bioactive Properties

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dc.authorid0000-0002-8901-6484
dc.authorid0000-0002-5151-2650
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMocan, Andrei
dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorPicot, Carene M. N.
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:12:36Z
dc.date.available2020-03-26T20:12:36Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study investigated into the polyphenolic content, antioxidant and enzyme (a-amylase, a-glucosidase, tyrosinase, acetylcholinesterase [AChE], and butyrylcholinesterase [BChE]) inhibitory activities of 12 extracts of the endemic Asphodeline cilicica (AC) Tuzlaci, from Turkey. The total phenolic content for the methanol and acetone extracts of AC roots were 56.52 and 52.96 mg GAEs/g extract, respectively. Both the acetone and methanol extracts of AC roots exhibited an important antioxidant capacity. Likewise, the acetone and methanol extracts of AC roots revealed to be the most potent scavengers of DPPH radical (58.25 and 58.78 mg TEs/g extract). Acetone extract of AC roots inhibited a-amylase showing an acarbose equivalent value (mmol ACAEs/g extract) of 0.27, while against a-glucosidase the value recorded was 2.30. The acetone and methanol extracts of the different plant parts of AC inhibited AChE and BChE, while no/poor activity was noted for the water extracts. In the present study, extracts of AC showed inhibitory activity against key enzymes involved in diabetes and neurodegenerative complications, thereby advocating for the need for in-depth studies geared towards the discovery of pharmacophores from this endemic plant. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.citationZengin, G., Aktümsek, A., Mocan, A., Rengasamy, K. R. R., Picot, C. M. N., Mahomoodally, M. F. (2019). Asphodeline cilicica Tuzlaci: From the plant to its most active part extract and its broad bioactive properties. South African Journal of Botany, 120, 186-190. doi: https://dx.doi.org/10.1016/j.sajb.2018.05.014
dc.identifier.doi10.1016/j.sajb.2018.05.014en_US
dc.identifier.endpage190en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.05.014
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37499
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsphodeline cilicica Tuzlacien_US
dc.subjectAntioxidanten_US
dc.subjectFlavonoidsen_US
dc.subjectNatural enzyme inhibitorsen_US
dc.subjectTurkeyen_US
dc.subjectAntioksidan
dc.subjectFlavonoidler
dc.subjectDoğal enzim inhibitörleri
dc.titleAsphodeline Cilicica Tuzlaci: From the Plant to Its Most Active Part Extract and Its Broad Bioactive Propertiesen_US
dc.typeArticleen_US

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