T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction

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dc.contributor.authorMutlu, N
dc.contributor.authorErdal, ME
dc.contributor.authorHerken, H
dc.contributor.authorOz, G
dc.contributor.authorBayazit, YA
dc.date.accessioned2020-03-26T16:55:30Z
dc.date.available2020-03-26T16:55:30Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS: Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique. RESULTS: The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05). CONCLUSION: The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level.en_US
dc.identifier.doi10.1111/j.1601-0825.2004.01037.xen_US
dc.identifier.endpage352en_US
dc.identifier.issn1354-523Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid15533210en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1601-0825.2004.01037.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19219
dc.identifier.volume10en_US
dc.identifier.wosWOS:000225014700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL MUNKSGAARDen_US
dc.relation.ispartofORAL DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttemporomandibular dysfunctionen_US
dc.subjectserotoninen_US
dc.subject5-HT2A receptoren_US
dc.subjectpolymorphismen_US
dc.titleT102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunctionen_US
dc.typeArticleen_US

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