Functional constituents of wild and cultivated Goji (L-barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies

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dc.contributor.authorMocan, Andrei
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSimirgiotis, Mario
dc.contributor.authorSchafberg, Michaela
dc.contributor.authorMollica, Adriano
dc.contributor.authorVodnar, Dan C.
dc.contributor.authorCrisan, Gianina
dc.date.accessioned2020-03-26T19:41:47Z
dc.date.available2020-03-26T19:41:47Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGoji (Lycium barbarum L.) leaves are emphasized as a functional tea or as dietary supplements. The phenolic compound profile, antioxidant, enzyme inhibitory, antimicrobial, and antimutagenic activities of leaf extracts from two selected cultivars in comparison with wild-growing plants have been evaluated. HPLCDAD/ ESI-ToF-MS analysis revealed the presence of phenolic acids and flavonoids with chlorogenic acid and rutin being the dominant compounds in the cultivated plants, whereas rutin and kaempeferol-3-O-rutinoside for wild growing ones. In particular, cv. Erma contained the highest amount of chlorogenic acid and showed a strong tyrosinase-inhibitory effect. Staphylococcus aureus, Listeria monocytogenes, and Penicillium funiculosum were the most sensitive strains when exposed to extracts from cultivated plants. Antimutagenic activity was evaluated by Ames' test. The tested extracts provided high protection against mutagenicity induced by 2-anthramine (2-AA) to Salmonella typhimurium strains TA 98 and TA 100 (max. inhibition (%) 88% and 74.2%, respectively). Overall, Goji leaves are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.en_US
dc.description.sponsorshipGerman Federal Environmental Foundation (DBU); European Social FundEuropean Social Fund (ESF); Human Resources Development Operational Program [POSDRU/159/1.5/S/136893]en_US
dc.description.sponsorshipAndrei Mocan was financed by a fellowship supported by the German Federal Environmental Foundation (DBU). He is currently financed by a project under the frame of European Social Fund, Human Resources Development Operational Program 2007-2013, project no. POSDRU/159/1.5/S/136893.en_US
dc.identifier.doi10.1080/14756366.2016.1243535en_US
dc.identifier.endpage168en_US
dc.identifier.issn1475-6366en_US
dc.identifier.issn1475-6374en_US
dc.identifier.issue1en_US
dc.identifier.pmid28095717en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14756366.2016.1243535
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35144
dc.identifier.volume32en_US
dc.identifier.wosWOS:000392591100009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntibacterial activityen_US
dc.subjectantimutagenicityen_US
dc.subjectenzyme inhibitionen_US
dc.subjectGoji leavesen_US
dc.subjectphenolic compoundsen_US
dc.titleFunctional constituents of wild and cultivated Goji (L-barbarum L.) leaves: phytochemical characterization, biological profile, and computational studiesen_US
dc.typeArticleen_US

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