The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.date.accessioned2020-03-26T19:07:28Z
dc.date.available2020-03-26T19:07:28Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30 d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.bbr.2014.10.032en_US
dc.identifier.endpage461en_US
dc.identifier.issn0166-4328en_US
dc.identifier.issn1872-7549en_US
dc.identifier.pmid25446810en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage453en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bbr.2014.10.032
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32644
dc.identifier.volume278en_US
dc.identifier.wosWOS:000347586300055en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofBEHAVIOURAL BRAIN RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGinkgo bilobaen_US
dc.subjectAgingen_US
dc.subjectCognitive functionen_US
dc.subjectMemoryen_US
dc.subjectOxidative stressen_US
dc.subjectBDNFen_US
dc.titleThe effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factoren_US
dc.typeArticleen_US

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