A Randomized Comparison of Dimenhydrinate, Metoclopramide and Placebo for the Prevention of Nausea and Vomiting Following Intrathecal Fentanyl and Morphine in Cesarean Delivery

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dc.contributor.authorDuman, Ateş
dc.contributor.authorApilioğulları, Seza
dc.contributor.authorGök, Funda
dc.contributor.authorSütçü, Erdinç
dc.contributor.authorSoysal, Sema
dc.contributor.authorToy, Harun
dc.date.accessioned2020-03-26T17:46:47Z
dc.date.available2020-03-26T17:46:47Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective Intrathecal morphine for cesarean section provides excellent postoperative analgesia however is associated with significant nausea and vomiting This study was designed to compare the effectiveness of prophylactic use of dimenhydrinate and metoclopramide to placebo for the prevention of nausea and vomiting following intrathecal fentanyl and morphine used for cesarean section Material and Method Two hundred ten patents undergoing cesarean section under spinal anesthesia were included in this double blind and randomized study Spinal anesthesia was performed with 10 mg of hyperbaric bupivacaine combined with 20 mu g fentanyl and 200 mu g morphine After clamping the umbilical cord patients were randomly allocated to receive 50 mg dimenhydrinate intravenously (Group D) 10 mg metoclopramide (Group M) or 0 9% NaCl as placebo (Group P) The incidence of postoperative nausea or vomiting (PONV) during the first 24 postoperative hours was evaluated Results The postoperative incidence of PONV was significantly lower in Group D (11%) than in Group M (28%) and Group P (32%) (p=0 02) The incidence and severity of postoperative nausea were significantly lower with the use of dimenhydrinate as compared to metoclopramide and placebo group (p= 0 01) Conclusion The prophylactic use of dimenhydrinate (50 mg intravenously) as compared either to metoclopramide (10 mg) or placebo effectively decreased the incidence of PONV following intrathecal fentanyl and morphine for cesarean section.en_US
dc.identifier.citationDuman, A., Apilioğulları, S., Gök, F., Sütçü, E., Soysal, S., Toy, H., (2010). A Randomized Comparison of Dimenhydrinate, Metoclopramide and Placebo for the Prevention of Nausea and Vomiting Following Intrathecal Fentanyl and Morphine in Cesarean Delivery. Nobel Medicus, 6(3), 13-19.
dc.identifier.endpage19en_US
dc.identifier.issn1305-2381en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24543
dc.identifier.volume6en_US
dc.identifier.wosWOS:000285677300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDuman, Ateş
dc.institutionauthorApilioğulları, Seza
dc.institutionauthorSütçü, Erdinç
dc.language.isoenen_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCesarean sectionen_US
dc.subjectDimenhydrinateen_US
dc.subjectFentanylen_US
dc.subjectMetoclopramide morphineen_US
dc.titleA Randomized Comparison of Dimenhydrinate, Metoclopramide and Placebo for the Prevention of Nausea and Vomiting Following Intrathecal Fentanyl and Morphine in Cesarean Deliveryen_US
dc.typeArticleen_US

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