Soluble CD40 Ligand Levels in Acute Pulmonary Embolism: A Prospective, Randomized, Controlled Study

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dc.contributor.authorKaya, Zeynettin
dc.contributor.authorÖzdemir, Kurtuluş
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorGül, Enes Elvin
dc.contributor.authorAltunbaş, Gökhan
dc.contributor.authorDuman, Çetin
dc.contributor.authorKıyıcı, Aysel
dc.date.accessioned2020-03-26T18:31:20Z
dc.date.available2020-03-26T18:31:20Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events. Platelets constitute the major source of soluble CD40 ligands (sCD40L), which has been shown to influence platelet activation. The main aim of this study was to evaluate sCD40L levels in patients with acute pulmonary embolism (PE). Sixty-five PE patients (32 males, mean age 58 +/- A 12 years) and 29 healthy controls (15 males, mean age 56 +/- A 14 years) were enrolled in the study. sCD40L levels were evaluated at the enrollment by ELISA method. Multislice detected pulmonary computed tomography was performed on all patients with a suspected diagnosis of PE. In addition, echocardiography was performed to evaluate right ventricular (RV) dysfunction. There was no statistically significant difference between the two groups regarding demographic features. sCD40L levels were significantly higher in acute PE group compared to healthy controls (5.3 ng/ml and 1.4 ng/ml, respectively; < 0.001). sCD40L levels of patients with and without RV dysfunction were similar. Correlation analysis between echocardiographic findings and sCD40L levels did not show significant difference. The present study demonstrated a role of sCD40L in pathogenesis of PE for the first time. Further studies are needed to clarify a predictive and prognostic value of sCD40L levels in acute PE patients.en_US
dc.identifier.citationKaya, Z., Özdemir, K., Kayrak, M., Gül, E. E., Altunbaş, G., Duman, Ç., Kıyıcı, A., (2012). Soluble CD40 Ligand Levels in Acute Pulmonary Embolism: A Prospective, Randomized, Controlled Study. Heart and Vessels, 27, 295-299. DOI 10.1007/s00380-011-0142-4
dc.identifier.doi10.1007/s00380-011-0142-4en_US
dc.identifier.endpage299en_US
dc.identifier.issn0910-8327en_US
dc.identifier.pmid21491121en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00380-011-0142-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28410
dc.identifier.volume27en_US
dc.identifier.wosWOS:000304142400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaya, Zeynettin
dc.institutionauthorÖzdemir, Kurtuluş
dc.institutionauthorKayrak, Mehmet
dc.institutionauthorGül, Enes Elvin
dc.institutionauthorAltunbaş, Gökhan
dc.institutionauthorDuman, Çetin
dc.institutionauthorKıyıcı, Aysel
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofHeart and Vesselsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPulmonary embolismen_US
dc.subjectSoluble CD40 liganden_US
dc.subjectThrombosisen_US
dc.subjectBiomarkeren_US
dc.titleSoluble CD40 Ligand Levels in Acute Pulmonary Embolism: A Prospective, Randomized, Controlled Studyen_US
dc.typeArticleen_US

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