Effect of Surgical Weight Loss on Free Radical and Antioxidant Balance: a Preliminary Report

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dc.contributor.authorKısakol, Gürcan
dc.contributor.authorGüney, Engin
dc.contributor.authorBayraktar, Fırat
dc.contributor.authorYilmaz, Candeğer
dc.contributor.authorKabalak, Taylan
dc.contributor.authorÖzmen, Dilek
dc.date.accessioned2020-03-26T16:38:55Z
dc.date.available2020-03-26T16:38:55Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: This study observes the effect of surgical weight loss on free radical and antioxidant vitamin balance. Patients and Methods: 22 consecutive morbidly obese patients undergoing vertical banded gastroplasty (VBG) were chosen for the study. Postoperative studies were done at 12 and 24 weeks. Plasma antioxidant and vitamin determinations were performed by HPLC method. Results: Subjects lost a significant amount of weight (P<0.01). Compared to preoperative measurements, postoperative measurements of plasma betacarotene were not statististically different both at 12 and 24 weeks (13.86&PLUSMN;1.26 &mu;g/dl, 12.35&PLUSMN;1.2, P=0.44; 14.33&PLUSMN;2.03, P=0.77; preoperatively, 12 and 24 weeks respectively). Alpha-tocopherol increased slightly at the 12th week; the difference was not significant (8.50&PLUSMN;0.77; 9.56&PLUSMN;0.82, P=0.37; preoperatively and 12th week respectively). The levels of alpha-tocopherol rose at 24th week significantly (10.89&PLUSMN;0.55, P=0.028). The indicator of lipid peroxidation (malondialdehyde) decreased with weight loss (1.505&PLUSMN;0.11 &mu;mol/L preoperatively; 0.75&PLUSMN;0.062 at 12th week, P=0.01; 0.712&PLUSMN;0.05 at 24th week, P<0.01). Conclusion: Our data show that free radical generation falls markedly in association with weight loss after VBG. Surgical weight loss leads to significant decrease in oxidant production and also leads to increase in some antioxidant vitamins. The demonstration of decreased free radical generation and correction of balance between free radicals and antioxidant vitamins has important implications for oxidative mechanisms underlying obesity-associated disorders.en_US
dc.identifier.citationKısakol, G., Güney, E., Bayraktar, F., Yılmaz, C., Kabalak, T., Özmen, D., (2002). Effect of Surgical Weight Loss on Free Radical and Antioxidant Balance: a Preliminary Report. Obesity Surgery, 12(6), 795-800. Doi: 10.1381/096089202320995574
dc.identifier.doi10.1381/096089202320995574en_US
dc.identifier.endpage800en_US
dc.identifier.issn0960-8923en_US
dc.identifier.issue6en_US
dc.identifier.pmid12568184en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage795en_US
dc.identifier.urihttps://dx.doi.org/10.1381/096089202320995574
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17931
dc.identifier.volume12en_US
dc.identifier.wosWOS:000180505600013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKısakol, Gürcan
dc.language.isoenen_US
dc.publisherF D-Communications Incen_US
dc.relation.ispartofObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmorbid obesityen_US
dc.subjectbariatric surgeryen_US
dc.subjectweight lossen_US
dc.subjectfree radicalsen_US
dc.subjectantioxidant vitaminsen_US
dc.titleEffect of Surgical Weight Loss on Free Radical and Antioxidant Balance: a Preliminary Reporten_US
dc.typeArticleen_US

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