Effect of Lycopene on Caspase-3 Enzyme Activation in Liver of Methanol-Intoxicated Rats: Comparison with Fomepizole

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dc.contributor.authorKurçer, Mehmet Ali
dc.contributor.authorKurçer, Zehra
dc.contributor.authorKöksal, Mete
dc.contributor.authorBaba, Füsun
dc.contributor.authorOcak, Ali Rıza
dc.contributor.authorAksoy, Nurten
dc.contributor.authorAteşşahin, Ahmet
dc.contributor.authorSahna, Engin
dc.date.accessioned2020-03-26T17:48:00Z
dc.date.available2020-03-26T17:48:00Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. This study was performed to evaluate the effect of lycopene on methanol-induced liver injury and to compare the results with those after fomepizole, which is used in treatment of methanol intoxication. Experiments were carried out with 30 female Wistar rats weighting 180-200 g. Rats were injected with a intraperitoneally dose of 3 g/kg methanol as a 50% solution in isotonic saline once for intoxication. Rats were pretreated with fomepizole (50 mg/kg) and/or lycopene (10 mg/kg) before methanol. After 24 hours all the drug-treated and intoxicated rats were sacrificed under anesthesia. Malondialdehyde (MDA) levels were determined in order to assess lipid peroxidation, and caspase-3 activity was determined by immunostaining of liver tissues to evaluate apoptosis. Methanol administration significantly increased the MDA level and caspase-3 activity in liver. Pretreatment with lycopene and/or fomepizole decreased the MDA levels significantly. Similarly, lycopene and fomepizole decreased methanol-induced caspase-3 activity. The findings of the present study demonstrate that methanol intoxication causes hepatic toxicity in rats and that this is likely a result of reactive oxygen species and apoptosis induction. Lycopene has protective effects against methanol-induced hepatic injury similar to fomepizole. It was demonstrated for the first time that both lycopene and fomepizole prevent methanol-induced hepatic injury by reducing the increase of lipid oxidation and caspase-3 activation.en_US
dc.identifier.citationKurçer, M. A., Kurçer, Z., Köksal, M., Baba, F., Ocak, Ali R., Aksoy, N., Ateşşahin, A., Sahna, E., (2010). Effect of Lycopene on Caspase-3 Enzyme Activation in Liver of Methanol-Intoxicated Rats: Comparison with Fomepizole. Journal of Medicinal Food, 13(4), 985-991. doi: org/10.1089/jmf.2009.0166
dc.identifier.doi10.1089/jmf.2009.0166en_US
dc.identifier.endpage991en_US
dc.identifier.issn1096-620Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid20482279en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage985en_US
dc.identifier.urihttps://dx.doi.org/10.1089/jmf.2009.0166
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24806
dc.identifier.volume13en_US
dc.identifier.wosWOS:000280485000030en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOcak, Ali Rıza
dc.institutionauthorAksoy, Nurten
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT INCen_US
dc.relation.ispartofJournal of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcaspase-3en_US
dc.subjectfomepizoleen_US
dc.subjectintoxicationen_US
dc.subjectliveren_US
dc.subjectlycopeneen_US
dc.subjectmethanolen_US
dc.subjectraten_US
dc.titleEffect of Lycopene on Caspase-3 Enzyme Activation in Liver of Methanol-Intoxicated Rats: Comparison with Fomepizoleen_US
dc.typeArticleen_US

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