Long-term Effect of Bosentan Therapy on Cardiac Function and Symptomatic Benefits in Adult Patients with Eisenmenger Syndrome

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dc.contributor.authorKaya, Mehmet G.
dc.contributor.authorLam, Y-Y.
dc.contributor.authorErer, Betül
dc.contributor.authorAyhan, Selim
dc.contributor.authorVatankulu, Mehmet A.
dc.contributor.authorNurkalem, Zekeriya
dc.contributor.authorMeric, Murat
dc.contributor.authorEryol, Namık K.
dc.contributor.authorEren, Mehmet
dc.date.accessioned2020-03-26T18:30:48Z
dc.date.available2020-03-26T18:30:48Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Bosentan improves symptoms in patients with Eisenmenger syndrome (ES). This study evaluated the effect of long-term bosentan therapy on cardiac function and its relation to symptomatic benefits in ES patients. Methods and Results: Twenty-three consecutive adult ES patients (15 with ventricular septal defect, 6 with atrial septal defect, and 2 with patent ductus arteriosus) underwent standard and tissue Doppler echocardiography before and 24 +/- 9 months after bosentan therapy. Echocardiographic measurements included pulmonary arterial systolic pressure (PASP), myocardial performance index (MPI), tricuspid and lateral mitral annular pulsed-wave tissue Doppler systolic (Sa) and early diastolic (Ea) long-axis motions. Patients' World Health Organization (WHO) functional class, 6-minute walk distance (6MWD), and systemic arterial oxygen saturations (SaO(2)) were also recorded. The PASP, WHO functional class, 6MWD, and SaO(2) all improved (118 +/- 22 to 111 +/- 19 mm Hg, 3.2 +/- 0.4 to 2.4 +/- 0.5, 286 +/- 129 m to 395 +/- 120 m, and 84.6 +/- 6.5% to 88.8 +/- 3.9%, respectively; all P < .01) after therapy. There was also significant improvement in right ventricular (RV) MPI (by 23.9%: 0.46 +/- 0.15 to 0.35 +/- 0.09) and biventricular long-axis function (tricuspid Sa and Ea: 6.7 +/- 1.5 to 8.8 +/- 1.7 cm/s and 5.7 +/- 1.3 to 7.0 +/- 1.2 cm/s, respectively; lateral Sa and Ea: 6.8 +/- 1.3 to 8.4 +/- 1.5 cm/s and 7.6 +/- 2.0 to 8.5 +/- 2.1 cm/s, respectively; all P < .05). Posttherapy RV MPI was moderately correlated with PASP and 6MWD. Conclusions: Sustained improvement of pulmonary arterial hypertension and RV function in ES patients was evident 2 years after bosentan therapy, and this may provide insights on the symptomatic benefits gained in these patients. (J Cardiac Fail 2012;18:379-384)en_US
dc.identifier.citationKaya, M, G., Lam, Y-Y., Erer, B., Ayhan, S., Vatankulu, M. A., Nurkalem, Z., Meric, M., Eryol, N. K., Eren, M., (2012). Long-term Effect of Bosentan Therapy on Cardiac Function and Symptomatic Benefits in Adult Patients With Eisenmenger Syndrome. Journal of Cardiac Failure, 18(5), 379-384. Doi:10.1016/j.cardfail.2012.02.004
dc.identifier.doi10.1016/j.cardfail.2012.02.004en_US
dc.identifier.endpage384en_US
dc.identifier.issn1071-9164en_US
dc.identifier.issn1532-8414en_US
dc.identifier.issue5en_US
dc.identifier.pmid22555267en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.cardfail.2012.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28198
dc.identifier.volume18en_US
dc.identifier.wosWOS:000304078700005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAyhan, Selim
dc.institutionauthorVatankulu, Mehmet A.
dc.language.isoenen_US
dc.publisherChurchill Livingstone Inc Medical Publishersen_US
dc.relation.ispartofJournal of Cardiac Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBosentanen_US
dc.subjectEisenmenger syndromeen_US
dc.subjectmyocardial performance indexen_US
dc.subjectlong-axis functionen_US
dc.titleLong-term Effect of Bosentan Therapy on Cardiac Function and Symptomatic Benefits in Adult Patients with Eisenmenger Syndromeen_US
dc.typeArticleen_US

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