Cyclosporine Effects on Clinical Findings and Impression Cytology Specimens in Severe Vernal Keratoconjunctivitis

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorErdöl, Hidayet
dc.contributor.authorKapıcıoğlu, Zerrin
dc.contributor.authorAkyol, Nurettin
dc.date.accessioned2020-03-26T16:37:01Z
dc.date.available2020-03-26T16:37:01Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the possible effects of topical cyclosporine eye drops 2% (CsA) on conjunctival immune cells obtained by impression cytology technique and to determine the clinical relevance of this effect if present. Methods: Ten consecutive patients with severe, resistant, and active vernal keratoconjunctivitis (VKC) were included in this study. All of them were treated with 2% of topical CsA drops. Symptom and clinical scores and conjunctival impression cytology specimens were obtained both before and following treatment. Impression cytology specimens were stained with anti-CD8+, CD4+, CD45RA+, and CD23+ antibodies and the percentages of positive cells were counted. The results were compared and correlation analyses were performed between clinical and laboratory data. Results: Significant reductions were observed with respect to the percentages of CD4+ and CD23+ cells in the conjunctival impression cytology specimens and clinical and symptom scores following treatment with topical CsA, while no change occurred in the percentages of CD8+ and CD45RA+ cells. The percentages of CD4+ and CD23+ cells showed good correlations with symptom and clinical scores. Conclusion: Topical CsA treatment is a very effective alternative in severe VKC cases in clinical ground and clinical efficacy of topical CsA treatment in severe, resistant VKC cases can be (at least partly) related to reduction of the CD23+ and CD4+ cell populations on the conjunctival surface.en_US
dc.identifier.citationAvunduk, A. M., Avunduk, M. C., Erdöl, H., Kapıcıoğlu, Z., Akyol, N., (2001). Cyclosporine Effects on Clinical Findings and Impression Cytology Specimens in Severe Vernal Keratoconjunctivitis. Ophthalmologica, 215(4), 290-293. DOI: 10.1159/000050876
dc.identifier.doi10.1159/000050876en_US
dc.identifier.endpage293en_US
dc.identifier.issn0030-3755en_US
dc.identifier.issn1423-0267en_US
dc.identifier.issue4en_US
dc.identifier.pmid11399937en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000050876
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17515
dc.identifier.volume215en_US
dc.identifier.wosWOS:000169289000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOphthalmologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectVernal Keratoconjunctivitisen_US
dc.subjectCyclosporineen_US
dc.subjectImpression Cytologyen_US
dc.subjectTreatmenten_US
dc.titleCyclosporine Effects on Clinical Findings and Impression Cytology Specimens in Severe Vernal Keratoconjunctivitisen_US
dc.typeArticleen_US

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