Serum oxidant and antioxidant status of patients with chronic tension-type headache: possible effects of medical treatment

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dc.contributor.authorCokal, Burcu Gokce
dc.contributor.authorAytac, Bilal
dc.contributor.authorDurak, Zahide Esra
dc.contributor.authorGunes, Hafize Nalan
dc.contributor.authorOzturk, Bahadir
dc.contributor.authorGuler, Selda Keskin
dc.contributor.authorDurak, Ilker
dc.date.accessioned2020-03-26T19:07:04Z
dc.date.available2020-03-26T19:07:04Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTension-type headache (TTH) is one of the most common and costly primary types of headache in clinical practice, with an unknown etiology. This study assessed to investigate oxidative and antioxidative status in patients with chronic tension-type headache (CTTH), and to evaluate possible effect of medical treatment. The study included 41 CTTH patients and 19 age- and sex-matched healthy subjects without headache as controls. The CTTH group comprised 20 patients receiving treatment and 21 untreated patients. We evaluated oxidant/antioxidant status by measuring serum malondialdehyde (MDA) levels and activities of antioxidant enzymes, namely glutathione peroxidase (GSH-Px) and catalase (CAT). Comparison of oxidative parameters in the patient and control groups revealed significantly lower CAT activities and higher MDA level and GSH-Px activities in the patient group. In the CTTH group, serum CAT activities were found to be significantly decreased in patient groups, while serum MDA levels and GSH-Px activities were found to be higher in the untreated CTTH patients. These findings suggest that oxidative stress is increased in the patients with CTTH, and medical treatment abolishes the stress in part. It has been concluded that antioxidant support might be helpful for the patients with CTTH to prevent oxidant stress and peroxidation damages further.en_US
dc.identifier.doi10.1007/s10072-015-2240-zen_US
dc.identifier.endpage1775en_US
dc.identifier.issn1590-1874en_US
dc.identifier.issn1590-3478en_US
dc.identifier.issue10en_US
dc.identifier.pmid25981224en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1771en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10072-015-2240-z
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32547
dc.identifier.volume36en_US
dc.identifier.wosWOS:000361821500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER-VERLAG ITALIA SRLen_US
dc.relation.ispartofNEUROLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTension-type headacheen_US
dc.subjectTreatmenten_US
dc.subjectOxidative stressen_US
dc.subjectMalondialdehydeen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.titleSerum oxidant and antioxidant status of patients with chronic tension-type headache: possible effects of medical treatmenten_US
dc.typeArticleen_US

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