Detection of p16 promotor hypermethylation in "Maras powder" and tobacco users

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dc.contributor.authorSaatci, Cetin
dc.contributor.authorCaglayan, Ahmet Okay
dc.contributor.authorOzkul, Yusuf
dc.contributor.authorTahiri, Serpil
dc.contributor.authorTurhan, Ahmet Bulent
dc.contributor.authorDundar, Munis
dc.date.accessioned2020-03-26T17:38:11Z
dc.date.available2020-03-26T17:38:11Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: A plant powder called "Maras powder" is widely used instead of cigarette smoking in the South-Eastern region of Turkey. It has been confirmed that this powder comprises tobacco Nicotiana rustica L. Methods: The aim of this study was to assess the effect of Maras powder and cigarette smoking on the PIS promotor hypermethylation. Twenty-two Maras powder users (Group I), 12 cigarette smokers (Group II), and 16 healthy controls who neither smoked nor used Maras powder (Group III)were included in the study. Hypermethylation of the P16 gene was examined using methylation-specific PCR (MSP) method in the blood of the three groups. Results: Aberrant PIS methylation was found in 7 of the 22 (31.8%) in Group I, in 3 of 12 (25%) in Group II, and in 1 of 16 (6.25%) in Group III. Conclusion: Maras powder may be as harmful as cigarette smoking, leading to hypermethylation in PIS and warrants detailed studies on this subject. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipErciyes University ResearchErciyes Universityen_US
dc.description.sponsorshipThis work was supported by Erciyes University Research Funding.en_US
dc.identifier.doi10.1016/j.canep.2009.04.018en_US
dc.identifier.endpage50en_US
dc.identifier.issn1877-7821en_US
dc.identifier.issn1877-783Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid19679047en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.canep.2009.04.018
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23397
dc.identifier.volume33en_US
dc.identifier.wosWOS:000269846400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofCANCER EPIDEMIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMaras powderen_US
dc.subjectMethylationen_US
dc.subjectP16en_US
dc.subjectSmokeless tobaccoen_US
dc.titleDetection of p16 promotor hypermethylation in "Maras powder" and tobacco usersen_US
dc.typeArticleen_US

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