An uncommon presentation of Sjogren's syndrome and brucellosis

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorOzturk, Ercument
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorYilmaz, Sema
dc.contributor.authorColkesen, Fatih
dc.contributor.authorBaldane, Suleyman
dc.contributor.authorKebapcilar, Levent
dc.date.accessioned2020-03-26T18:49:22Z
dc.date.available2020-03-26T18:49:22Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe describe herein a case of hypokalemia due to proximal renal tubular acidosis (RTA) and Fanconi's syndrome (FS) and nephrogenic diabetes insipidus with DIC - a rare complication of Sjogren's syndrome (SS) and brucellosis. The interesting feature of this case was the presentation with severe hypokalemia, causing acute flaccid quadriparesis with cardiac arrest which is extremely rare. The patient was a 48-year-old woman who suffered cardiopulmonary arrest an hour after hospitalization. Analysis of a blood sample obtained before her cardiopulmonary arrest yielded surprising results: laboratory investigations showed profound hypokalemia (1.1 mEq/L) with renal K wasting, hyperchloremic metabolic acidosis with normal anion gap, hypophosphatemia with hypouricemia, glucosuria, and proteinuria. A diagnosis of RTA and FS were made. On the seventh day, she looked acutely ill, temperature 38.8 C and pale, and her physical examination revealed purpuric skin lesions on both legs. The serum antibrucella titration agglutination test was found to be 1 of 160 positive with a nosocomial infection. The clinical and laboratory findings were consistent with disseminated intravascular coagulation (DIC). She was unable to concentrate her urine and so a diagnosis of nephrogenic diabetes insipidus (NDI) was reached. A thorough survey for the cause of FS, RTA and NDI revealed that she had xerophthalmia and xerostomia accompanied by high anti-Ro antibody, positive Schirmer test, confirming the diagnosis of SS. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2014.03.011en_US
dc.identifier.endpage80en_US
dc.identifier.issn1473-0502en_US
dc.identifier.issue1en_US
dc.identifier.pmid25108849en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.transci.2014.03.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30594
dc.identifier.volume51en_US
dc.identifier.wosWOS:000345185700019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofTRANSFUSION AND APHERESIS SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSjogren's syndromeen_US
dc.subjectHypokalemiaen_US
dc.subjectFanconi's syndromeen_US
dc.subjectNephrogenic diabetes insipidusen_US
dc.subjectDisseminated intravascular coagulationen_US
dc.titleAn uncommon presentation of Sjogren's syndrome and brucellosisen_US
dc.typeArticleen_US

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