Mood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorder

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dc.contributor.authorAydin, Adem
dc.contributor.authorSelvi, Yavuz
dc.contributor.authorBesiroglu, Lutfullah
dc.contributor.authorBoysan, Murat
dc.contributor.authorAtli, Abdullah
dc.contributor.authorOzdemir, Osman
dc.contributor.authorKilic, Sultan
dc.date.accessioned2020-03-26T18:42:33Z
dc.date.available2020-03-26T18:42:33Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIt has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression-dejection among healthy controls. A paradoxical effect was defected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression-dejection and anger-hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression-dejection, anger-hostility, and confusion-bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine Functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipPsychiatric Association of Turkeyen_US
dc.description.sponsorshipThe authors gratefully acknowledge a financial support for this research awarded by "Psychiatric Association of Turkey".en_US
dc.identifier.doi10.1016/j.jad.2013.04.007en_US
dc.identifier.endpage294en_US
dc.identifier.issn0165-0327en_US
dc.identifier.issn1573-2517en_US
dc.identifier.issue2en_US
dc.identifier.pmid23664567en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jad.2013.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29657
dc.identifier.volume150en_US
dc.identifier.wosWOS:000323563300016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBipolar disorderen_US
dc.subjectEndophenotypeen_US
dc.subjectMood statesen_US
dc.subjectEndocrine systemen_US
dc.subjectHormonesen_US
dc.subjectSleep deprivationen_US
dc.titleMood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorderen_US
dc.typeArticleen_US

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