Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis

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dc.contributor.authorKeles, Bahar
dc.contributor.authorCora, Tuelin
dc.contributor.authorAcar, Hasan
dc.contributor.authorArbag, Hamdi
dc.contributor.authorInan, Ziya
dc.contributor.authorOzturk, Kayhan
dc.contributor.authorOzer, Bedri
dc.date.accessioned2020-03-26T17:26:50Z
dc.date.available2020-03-26T17:26:50Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description5th Balkan Congress of Otorhinolaryngology-Head and Neck Surgery -- SEP 07-10, 2006 -- Edirne, TURKEYen_US
dc.description.abstractOBJECTIVE: To evaluate whether there is a relationship between HLA-A, -B, -Cw, and -DRB1 alleles and developing nasal polyposis (NP). STUDY DESIGN: Data from 66 patients with NP were compared with data from 100 healthy randomly selected controls. Asthma, ASA (acetylsalicylic acid) triad, polyp score, and previous sinonasal surgery were also recorded. SUBJECTS AND METHODS: Genotyping of the HLA-A, -B, -Cw, and -DRB1 alleles were performed with polymerase chain reaction (PCR) with the sequence-specific primer (SSP) method. Data were analyzed by using a Pearson chi(2) test. RESULTS: The HLA-B*07 and -Cw*12 alleles were found to be significantly higher in the NP patients compared with the control group, whereas the HLA-B*57 and HLA-Cw*04 alleles were significantly lower (P < 0.05). The HLA-A*24, HLA-Cw*12, and HLA-DRB1*04 alleles were determined to be significantly higher in the NP patients with asthma and ASA triad (P < 0.05). CONCLUSIONS: Our results show that some of the HLA alleles seem to be associated with the genetic susceptibility to develop NP in the Turkish population. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.en_US
dc.identifier.doi10.1016/j.otohns.2008.07.002en_US
dc.identifier.endpage585en_US
dc.identifier.issn0194-5998en_US
dc.identifier.issn1097-6817en_US
dc.identifier.issue4en_US
dc.identifier.pmid18922348en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage580en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.otohns.2008.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22390
dc.identifier.volume139en_US
dc.identifier.wosWOS:000259767200018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofOTOLARYNGOLOGY-HEAD AND NECK SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEvaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposisen_US
dc.typeArticleen_US

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