Atorvastatin Pretreatment Diminishes the Levels of Myocardial Ischemia Markers Early After CABG Operation: An Observational Study

Basit Öğe Kaydı
dc.contributor.authorEge, Erdal
dc.contributor.authorDereli, Yüksel
dc.contributor.authorKurban, Sevil
dc.contributor.authorSarıgül, Ali
dc.date.accessioned2020-03-26T17:47:10Z
dc.date.available2020-03-26T17:47:10Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Statin pretreatment has been associated with a decrease in myocardial ischemia markers after various procedures and cardiovascular events. This study examined the potential beneficial effects of preoperative atorvastatin treatment among patients undergoing on-pump CABG operation. Methods: Twenty patients that had received atorvastatin treatment for at least 15 days prior to the operation and 20 patients who had not received any antihyperlipidemic agent prior to surgery were included in this study. CK-MB and troponin I levels were measured at baseline and 24 hours after the operation. Perioperative variables were also recorded. Results: Twenty-four hours after the operation, troponin I and CK-MB levels were significantly lower in the atorvastatin group: for CK-MB levels, 12.9 +/- 4.3 versus 18.7 +/- 7.4 ng/ml, p = 0.004; for troponin I levels, 1.7 +/- 0.3 versus 2.7 +/- 0.7 ng/ml, p < 0.001. In addition, atorvastatin use was associated with a decrease in the duration of ICU stay. Conclusions: Preoperative atorvastatin treatment results in significant reductions in the levels of myocardial injury markers early after on-pump CABG operation, suggesting a reduction in perioperative ischemia in this group of patients. Further studies are needed to elucidate the mechanisms of these potential benefits of statin pretreatment.en_US
dc.identifier.citationEge, E., Dereli, Y., Kurban, S., Sarıgül, A., (2010). Atorvastatin Pretreatment Diminishes the Levels of Myocardial Ischemia Markers Early After CABG Operation: an Observational Study. Journal of Cardiothoracic Surgery, (5), 1-6. Doi: 10.1186/1749-8090-5-60
dc.identifier.doi10.1186/1749-8090-5-60en_US
dc.identifier.endpage6
dc.identifier.issn1749-8090en_US
dc.identifier.pmid20707894en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1186/1749-8090-5-60
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24637
dc.identifier.volume5en_US
dc.identifier.wosWOS:000282339000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEge, Erdal
dc.institutionauthorSarıgül, Ali
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofJournal of Cardiothoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAtorvastatin Pretreatment Diminishes the Levels of Myocardial Ischemia Markers Early After CABG Operation: An Observational Studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
4637.pdf
Boyut:
526.2 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Kalp ve Damar Cerrahisi/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu