Fluid replacement via the rectum for treatment of hypovolaemic shock in an animal model

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dc.contributor.authorGirisgin, A. S.
dc.contributor.authorAcar, F.
dc.contributor.authorCander, B.
dc.contributor.authorGul, M.
dc.contributor.authorKocak, S.
dc.contributor.authorBodur, S.
dc.date.accessioned2020-03-26T17:03:36Z
dc.date.available2020-03-26T17:03:36Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The importance of early and effective fluid resuscitation in hypovolaemic shock treatment is indisputable. Aim: To examine the effects of fluid replacement via the rectum in an animal model of hypovolaemic shock as a possible life-saving method in situations where veins cannot be accessed quickly. Methods: Rabbits were randomly divided into two groups: a control group of 7 animals and a second group of 10, the fluid replacement via the rectum (FRVR) group. The femoral artery of each subject was catheterised and 15 ml blood was withdrawn over 1 min at 5-min intervals. After reaching a mean arterial pressure ( MAP) of 30 mm Hg, additional blood was withdrawn until the MAP dropped to,25 mm Hg, at which time blood withdrawal ceased. At this point, control animals were given no treatment and were monitored for 30 min. The FRVR group, however, was given 0.9% sodium chloride solution ( amount equal to three times the amount of blood withdrawn) via the rectum over a 15-min period. The MAPs of both groups were then measured, every 5 min after the start of resuscitation, for 30 min. Results: In the FRVR group, the MAP began to rise significantly after 15 min of receiving fluid per rectum ( p = 0.035) and continued to be significantly greater than the control group at 20, 25 and 30 min ( p = 0.035, 0.002 and 0.001, respectively). Conclusion: FRVR is a viable alternative for fluid resuscitation in this animal model of hypovolaemic shock. This easy and non-invasive method of fluid replacement may be useful when standard intravenous access is unobtainable, and should be compared with other access routes using varying types and amounts of fluids in future animal studies.en_US
dc.identifier.doi10.1136/emj.2005.032425en_US
dc.identifier.endpage864en_US
dc.identifier.issn1472-0205en_US
dc.identifier.issue11en_US
dc.identifier.pmid17057139en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage862en_US
dc.identifier.urihttps://dx.doi.org/10.1136/emj.2005.032425
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20504
dc.identifier.volume23en_US
dc.identifier.wosWOS:000241432600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherB M J PUBLISHING GROUPen_US
dc.relation.ispartofEMERGENCY MEDICINE JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleFluid replacement via the rectum for treatment of hypovolaemic shock in an animal modelen_US
dc.typeArticleen_US

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