Expression of cyclin A, cyclin E and p27 in normal, hyperplastic and frankly malignant endometrial samples

Basit Öğe Kaydı
dc.contributor.authorGezginc, S. T.
dc.contributor.authorCelik, C.
dc.contributor.authorDogan, N. U.
dc.contributor.authorToy, H.
dc.contributor.authorTazegul, A.
dc.contributor.authorColakoglu, M. C.
dc.date.accessioned2020-03-26T18:41:55Z
dc.date.available2020-03-26T18:41:55Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCellular growth is under the control of certain molecules such as cyclins and cyclin dependent kinases. Dysregulation of these proteins disrupt cell cycle and may trigger malignant transformation. Cyclins and kinase inhibitors also play essential roles in endometrial cellular proliferation. But the exact roles of these mediators in the disease process is not clear. We evaluated expression of cyclin A, cyclin E and p27 in normal, hyperplastic and malignant endometrial samples assuming different expression patterns in physiological and pathological processes. A total of 75 patients with histopathological diagnosis of normal proliferative, hyperplastic or malignant endometrial samples were evaluated with different cellular proliferation markers, cyclin A, cyclin E and p27. For cyclin E, endometrial cancer samples had higher rate of immunoreactivity than normal proliferative and hyperplastic endometrial samples. Staining properties for cyclin A were comparable for three groups. However, p27 immunoreactivity decreased progressively as lesions progress from proliferative benign endometrium to frank carcinoma. Further large-scale studies with clinical follow-up will reveal the exact role of cyclins on endometrial carcinogenesis.en_US
dc.identifier.doi10.3109/01443615.2013.776024en_US
dc.identifier.endpage511en_US
dc.identifier.issn0144-3615en_US
dc.identifier.issue5en_US
dc.identifier.pmid23815208en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage508en_US
dc.identifier.urihttps://dx.doi.org/10.3109/01443615.2013.776024
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29502
dc.identifier.volume33en_US
dc.identifier.wosWOS:000322417700019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCyclin Aen_US
dc.subjectcyclin Een_US
dc.subjectendometrial canceren_US
dc.subjectendometrial hyperplasiaen_US
dc.subjectp27en_US
dc.subjectproliferative endometriumen_US
dc.titleExpression of cyclin A, cyclin E and p27 in normal, hyperplastic and frankly malignant endometrial samplesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu