Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma

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dc.contributor.authorBozkurt, Banu
dc.contributor.authorMesci, Lutfiye
dc.contributor.authorIrkec, Murat
dc.contributor.authorOzdag, Burcin B.
dc.contributor.authorSanal, Ozden
dc.contributor.authorArslan, Umut
dc.contributor.authorErsoy, Fugen
dc.date.accessioned2020-03-26T18:24:02Z
dc.date.available2020-03-26T18:24:02Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Tumour necrosis factor-alpha (TNF-a) is an important proinflammatory cytokine driving axonal degeneration and retinal ganglion cell apoptosis in glaucoma. The aim of the study was to evaluate the association of TNF-a -308 G/A and -238 G/A polymorphisms with primary open-angle glaucoma (POAG). Design: A prospective, casecontrol study, university hospital setting. Participants: Eighty-six POAG patients and 193 healthy unrelated controls. Methods: TNF-a polymorphisms were screened by using direct gene sequencing. Main Outcome Measures: Frequency of TNF-a -308 G/A and TNF-a -238 G/A promoter polymorphisms in glaucoma and healthy subjects. Results: The frequencies of TNF-a -308 GA genotype and A allele were higher in patients with POAG (22.1% and 12.2%, respectively) in comparison with the control group (10.9% and 6%, respectively) (P = 0.046 and 0.02, respectively), with odds ratios of 2.45 (P = 0.01, 95% CI = 1.234.87) and 2.19 (P = 0.013, 95% CI = 1.184.08), respectively. Genotype distribution of the TNF-a -238 variants did not yield a statistically significant difference between the two groups (P = 0.87). Conclusion: TNF-a -308 G/A polymorphism seems to be associated with POAG in Turkish population. However, population-based studies with large number of subjects and long-term follow-up are needed to verify the association of TNF-a -308 G/A polymorphism with glaucoma susceptibility.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-HD-152 (106S226)]en_US
dc.description.sponsorshipThis project was supported by grants from TUBITAK (The Scientific and Technological Research Council of Turkey) - SBAG-HD-152 (106S226).en_US
dc.identifier.doi10.1111/j.1442-9071.2011.02595.xen_US
dc.identifier.endpageE162en_US
dc.identifier.issn1442-6404en_US
dc.identifier.issue4en_US
dc.identifier.pmid21575121en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE156en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1442-9071.2011.02595.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27774
dc.identifier.volume40en_US
dc.identifier.wosWOS:000305283600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdirect gene sequencingen_US
dc.subjectprimary open-angle glaucomaen_US
dc.subjectTNF-alpha-308 Gen_US
dc.subjectA polymorphismen_US
dc.subjectTNF-alpha-238 Gen_US
dc.subjectA polymorphismen_US
dc.subjectTurkish populationen_US
dc.titleAssociation of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucomaen_US
dc.typeArticleen_US

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