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Öğe 3 ', 4 '-dihydroxyflavonol attenuates tissue damage in unilateral testis ischemia-reperfusion in rats(COMENIUS UNIV, 2015) Duman, A.; Mogulkoc, R.; Baltaci, A. K.; Menevse, E.The purpose of this study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on oxidative damage and antioxidant system in experimental testicular torsion-detorsion. The study included 60 male Wistar albino rats. Study groups were formed as follows: 1. Control; 2. Sham; 3. 720 degrees - 4 hours torsion; 4. 720 degrees - 4 hours torsion + 4 hours detorsion; 5. 720 degrees - 4 hours torsion + DiOHF; 6. 720 degrees - 4 hours torsion + DiOHF + 4 hours detorsion; 7. 720 degrees - 4 hours torsion + 24 hours detorsion; 8. 720 degrees - 4 hours torsion + DiOHF + 24 hours detorsion. Testis were collected for the analysis of glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), and xanthine oxidase (XO). GPx in the Group 8 were higher than the values in the other groups (p < 0.001). Concerning NO, the groups 3, 4, and 7 were found to have higher values than other groups (p < 0.001). MDA levels were higher in the groups 3, 7, and 8, when compared to the levels in other groups (p < 0.001). When tissue GSH levels were examined, the Group 5 had the highest GSH values (p < 0.001). With regard to XO values, the groups 3, 4, and 7 had the highest XO values (p < 0.001). The results of the study indicated that intraperitoneal DiOHF inhibited increased lipid peroxidation in testis ischemia-reperfusion injury in rats (Tab. 5, Ref. 46). Text in PDF www.elis.sk.Öğe COMPARISON OF 7.5% NACL/6% DEXTRAN 70 AND 0.9% NACL ON SERUM SODIUM LEVELS IN PATIENTS UNDERGOING TRANSURETHRAL RESECTION OF PROSTATE(WILEY-BLACKWELL, 2011) Duman, A.; Zeydanoglu, Z.; Duman, I[Abstract not Available]Öğe The Comparison of Bupivacaine-Tramadol Combination With Bupivacaine-Fentanyl and Plain Bupivacaine in Epidural Anesthesia(2002) Kesriklioğlu, A.; Duman, A.; Öztin, Öğün C.; Reisli, R.; Ökeşli, S.In this study, the properties of epidural anesthesia with 0.5% bupivacaine and tramadol was compared with epidural anesthesia using bupivacaine-fentanyl or plain bupivacaine. For this purpose, 63 patients undergoing transuretral prostate resection were divided into three groups. Group BT(n = 22) received 70mg 0.5% bupivacaine + 50 mg tramadol HCl, Group BF(n = 21) received 70mg 0.5% bupivacaine + 50 ?g fentanyl and Group B(n = 20) received only 70mg 0.5% bupivacaine epidurally. Heart rate (HR), mean arterial pressure (MAP), breath rate (BR), oxygen saturation (SpO2), levels of sensorial block, maximum sensorial block level and motor block level were recorded. Time to need for an analgesic supplement (effective analgesia) (time to reach VAS 4) was recorded. One way analysis of variance, Tukey HSD, Kruskall Wallis, Bonferroni corrected Mann-Whitney-U tests were used. No significant change in HR was seen in between the three groups after the epidural block. A significant decrease of MAP was seen in Group BF beginning at the 40th minute lasted up to the 60th minute. Time to reach T10 sensory block level and time to reach maximum sensory block level was shorter in Group BF than Groups BT and B while Group BT and Groups B were similar. Time to complete motor block was similar in Group BT and BF. The number of patients with complete motor block was similar in Group BT and BF while there was no patient with complete motor block in Group B. The time to reach VAS 4 was 17.57 ± 7.82 hours in Group BT, 11.79 ± 8.48 hours in Group BF and 5.40 ± 2.67 hours in Group B (p < 0.05). Side effects were similar and no treatment was needed. In conclusion, tramadol-bupivacaine combination increases postoperative analgesia time significantly compared with fentanyl-bupivacaine combination and plain bupivacaine while providing stabile hemodynamic responses and similar side effects.Öğe COMPARISON OF DIMENHYDRINATE, METOCLOPRAMIDE AND PLACEBO FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER INTRATHECAL MORPHINE(WILEY-BLACKWELL, 2011) Duman, A.; Apiliogullari, S.; Gok, F.; Sutcu, E.; Soysal, S.; Toy, H.[Abstract not Available]Öğe Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study(LIPPINCOTT WILLIAMS & WILKINS, 2007) Apiliogullari, S.; Keles, B.; Apiliogullari, B.; Balasar, M.; Yilmaz, H.; Duman, A.Background and objective: Pain on injection is still a problem with propofol. The purpose of the study was to compare the effectiveness of diphenhydramine and lidocaine on pain caused by propofol at the site of injection. Methods: One hundred and eighty ASA I-II adults undergoing elective surgery were randomly assigned into three groups of 60 each. Group I (placebo) received 2 mL normal saline, Group 11 received 2 mL (40 mg) 2% lidocaine and Group III received 2 mL (20 mg) diphenhydramine intravenously (i.v.) during a 1-min venous occlusion, followed by propofol into a cephalic forearm vein of the antecubital fossa. Pain assessment was made immediately after propofol injection. Results: In the placebo group 25 (41.7%) patients experienced pain during propofol injection as compared to 2 (3.3%) and 3 (5.0%) in the lidocaine and diphenhydramine groups, respectively. The prevalence of pain and pain score were significantly less in both the lidocaine and diphenhydramine groups than in the placebo group (P = 0.00). No difference was found between the diphenhydramine and lidocaine groups (P = 0.60). Conclusion: Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins.Öğe The Comparison of Postoperative Analgesic Effects of Preemptive Ketamine and Fentanyl Use in Mastectomy Operations(2001) Öğün, C. Ö.; Duman, A.; Ökeşli, S.The aim of this study was to compare the efficacy of preemptive analgesia with fentanyl or ketamine in women undergoing mastectomy for breast cancer. ASA I-II, 47 women scheduled for mastectomy were included in the study. For all patients, anesthesia was induced with thiopentale, vecuronium and maintained with O 2:N 2O (30:70) + isoflurane. Heart rate (HR), mean arterial pressure (MAP), peripheral O 2 saturation (SpO 2) were monitored. After the induction of anesthesia, the patients were randomly divided in three groups: Group K (n=16) received 1 mg/kg ketamine, while group F (n=16) received 1 ?g/kg fentanyl before the skin incisions and after excision of the specimens. Group P received isotonic saline at sametimes. No other analgesic drugs were used intraoperatively. HR, MAP, extubation times, emergency times, respiration rate, SpO 2, side effects were recorded and postoperative pain was evaluated by visual analogue scale (VAS; 0-10) and verbal rating scale (VRS) in the recovery room at full emergence (0), 1st, 2nd, 4th, 12th and 24th hours. Postoperative analgesic requirements (meperidine) were recorded. The comments of anaesthesiologist and patients about postoperative period were also evaluated. There were no differences in weight, age, emergence times, extubation times. Hemodynamic and respiratory parameters, VAS and VRS scores and meperidine requirements were similar at all times between the group K and F. The increase of postoperative nausea and vomiting in group F was significantly higher than group P but was similar between group K and P and group K and F (p<0.05). As a conclusion, both ketamine and fentanyl have premptive effects in patients undergoing mastectomy but we think that analgesic effects are probably due to administirating ketamine and fentanyl both before surgical incision and before wound closure.Öğe DOPAMINERGIC CHALLENGE WITH BROMOCRIPTINE IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY(ELSEVIER, 2015) Celik, J. B.; Duman, A.; Arun, O.; Onal, I. O.[Abstract not Available]Öğe Effect of Dexmedetomidine on Pain Caused by Injection of Propofol(2012) Şarkılar, G.; Kara, I.; Duman, A.; Aygın, F.; Ökeşli, S.Objective: This study was designed to assess the local and systemic effects of two different pre-anesthetic infusion dose of dexmedetomidine in preventing propofol injection pain. Material and Method: Two hundred fifty adults were assigned into five groups. Before injection of propofol, group 1 (placebo n=50) received an infusion of saline solution, group 2 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 3 (n=50) received 1 ?g kg -1 of dexmedetomidine from the same vein. Group 4 (n=50) received 0.5 ?g kg -1 of dexmedetomidine and group 5 (n=50) received 1 ?g kg -1 dexmedetomidine followed by an injection of propofol from a vein located in the opposite hand. Pain assessment was made immediately after propofol injection. Results: Two hundred twenty five patients completed the study. The number of patients who suffered from any degree of pain was significantly high when compared to dexmedetomidine group (p=0.05). When compared with placebo and opposite hand, administering dexmedetomidine from the same vein was more efficient to prevent propofol pain (p=0.003). 1 ?g kg -1 of dexmedetomidine was similar to 0.5 ?g kg -1 of dexmedetomidine in preventing propofol pain.Conclusion: Dexmedetomidine infusions in pre-anesthetic sedative doses of 0.5 ?g kg -1 and 1 ?g kg -1 decrease the incidence of propofol injection pain compared to placebo.Öğe The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia(COMENIUS UNIV, 2019) Oc, B.; Arun, O.; Taylan, S. B.; Oc, M.; Bariskaner, H.; Duman, A.OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10(-9), 0(-6) M) dexmedetomidine were recorded at 37 degrees C and at 28 degrees C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37 degrees C dexmedetomidine resulted in similar signifi cant concentration-dependent contractions in both E+ and E-SV strips (p < 0.05). At 37 degrees C dexmedetomidine resulted in signifi cant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E-compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E-at 37 degrees C and also E-28 degrees C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV graftsÖğe The Effects of Intrathecal Morphine on Patient-controlled Analgesia, Morphine Consumption, Postoperative Pain and Satisfaction Scores in Patients Undergoing Gynaecological Oncological Surgery(SAGE PUBLICATIONS LTD, 2012) Kara, I.; Apiligullari, S.; Oc, B.; Celik, J. B.; Duman, A.; Celik, C.; Dogan, N. U.OBJECTIVE: Gynaecological oncological surgery (GOS) includes a wide variety of surgical procedures and postoperative pain is a major concern. This study compared the impact of intrathecal morphine (ITM) plus patient-controlled analgesia (PCA) with PCA alone on morphine consumption, pain relief and patient satisfaction after GOS. METHODS: Sixty women undergoing GOS under general anaesthesia were randomized to receive either 0.3 mg ITM or placebo. On arrival at the postanaesthesia care unit each patient received a morphine PCA pump. The three primary outcome measures were pain, patient satisfaction scores evaluated using a 100-mm visual analogue scale and cumulative PCA morphine consumption. RESULTS: No significant differences were observed in the demographic data. Cumulative PCA morphine consumption was significantly lower in the ITM group compared with the control group. Fatigue scores were lower in the ITM group compared with the control group but did not reach statistical significance. Pain, sedation and patient satisfaction scores, and the rate of side-effects were similar for the two groups. CONCLUSIONS: Administering ITM in GOS could improve postoperative analgesia and reduce morphine consumption without serious side-effects.Öğe Effects of Nimodipine on Tissue Lactate and Malondialdeyde Levels in Experimental Head Trauma(Australian Soc Anaesthetists, 2001) Ak, A.; Üstün, M. E.; Ogün, C. O.; Duman, A.; Bor, M. A.We studied the effects of nimodipine on brain tissue lactate and malondialdehyde (MDA) levels one hour after experimental head trauma in 25 New Zealand rabbits. Group 1(n=5) was the sham operated group. Group 2 (n=10) received head trauma without treatment and in group 3 (n=10) nimodipine was administered for 30 minutes intravenously (2 mug/kg/min) immediately after head trauma. In groups 2 and 3, tissue samples from the nontraumatized side was named as "a" and traumatized side as "b". The lactate and malondialdehyde contents were significantly higher in groups 2a, 2b, 3a and 3b when compared with to group 1 (P <0.05). The differences between non-treated groups (2a, 2b) and nimodipine treated groups (3a, 3b) were not significant (P >0.05). The differences between the traumatized sides (2b, 3b) and non-traumatized sides (2a, 3a) were significant (P <0.05). These results demonstrated that nimodipine is ineffective in suppressing the increase of tissue lactate and malondialdehyde levels in the early period of experimental head trauma.Öğe EFFECTS OF UNCONTROLLED DIABETES ON LDL LEVELS OF PATIENTS UNDERGOING CAROTID ENDARTERECTOMY ON AND OFF STATIN THERAPY: PRELIMINARY STUDY(ELSEVIER, 2015) Oc, M.; Duman, I.; Oc, B.; Simsek, M.; Vatansev, H.; Arun, O.; Duman, A.[Abstract not Available]Öğe Epidural Administration of Midasolam for Chronic Central Pain and Spasticity in Spinal Cord Injured Patients(1997) Özerbil, O. M.; Duman, A.; Yosunkaya, A.; Bayram, A.; Üstün, M. E.In the patients with spinal cord injury (SCI) chronic pain and spasticity affect significantly both the efficacy of rehabilitation and the quality of life. Recently it was shown that intrathecally and epidurally administered midasolam has analgesic and antispatic effects in both animals and humans so that it constitutes an alternative to be used in patients with SCI. In this study, four paraplegics who suffered from chronic central pain and spasticity in their lower extremities were given midasolan 6 times daily (dose 40 ?g/kg dose dissolved in 10 ml normal saline) via lumbar epidural catheter using pain management provider. Spasticity was monitored by means of a modified Ashwort scale, and pain evaluation was performed by face scale and VAS. The patients were hospitalized at least for two weeks and were observed for the efficacy of the drug. Although epidural administration of midasolam relieved both central pain and spasticity, it's efficacy on central pain was more pronounced. There were no significant side effects is any patient. We propose that midasolam may be given by epidural catheter or implantable drug pump for the treatment of central pain and/or spinal spasticity in spinal cord injured patients.Öğe Prevention of Postoperative Nausea-Vomiting in Children: Comparison of Granisetron and Droperidol Plus Metoclopramide(2001) Çelik, J.; Reisli, R.; Tuncer, S.; Duman, A.; Ökeşli, S.This study was performed to compare the efficacy of a droperidol-metoclopramide combination with granisetron to prevent postoperative nausea and vomiting after tonsillectomy with or without adenoidectomy in children. Ninety pediatric patients, ASA class I, aged 4-10 years, were enrolled in a prospective, randomized, double-blind investigation and assigned to one of two treatment regimens; granisetron 40 mg/kg (Group G, n=45), droperidol 50 mg/kg plus metoclopramide 0.25 mg/kg (Group DM, n=45). Antiemetic drugs were administered intravenaously (IV) after inhaled induction of general anaesthesia. The same standard general anesthetic technique was used. Tracheal extubation was performed while patients were still deeply anaesthetized. Acetaminophen (10-25 mg/kg PR) was applied for postoperative analgesia to all children. The rate of complete response, defined as no emesis and no need for rescue antiemetics, 0-3 h after anaesthesia were 85% in group G, 87% in group DM (p>0.05). No clinically important adverse events were observed in any of the groups.Öğe Successful surgical treatment of Nicolau's syndrome combined with intravenous iloprost(VERLAG HANS HUBER, 2009) Gormus, N.; Tanyeli, O.; Senaran, H.; Duman, A.; Gormus, Z. I. Solak; Durgut, K.A 4 year-old boy was admitted to our clinic with symptoms of pain and ecchymosis in his right leg and foot after injection of benzathine penicilline. There was a localized gangrenous area at the femoral injection site. Doppler ultrasonography showed no arterial flow in the femoral artery and clear evidence of acute thrombosis of the superficial femoral and popliteal veins. Femoral arterial and venous thrombectomy and fasciotomy were performed immediately. After surgery the boy was treated by Iloprost infusion and enoxaparine. One week later necrotic changes had regressed, fasciotomies were closed and only the distal phalanx of the third toe needed amputation. Early surgical intervention and standard management combined with Iloprost infusion may help in healing the lesions by increasing extremity perfusion and may prevent extremity loss.
