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Öğe 677C > T and 1298A > C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta(Turkish Neurosurgical Soc, 2010) Eser, Betül; Coşar, Murat; Eser, Olcay; Erdoğan, Müjgan O.; Aslan, Adem; Yıldız, Handan; Boyacı, Gazi; Büyükbaş, Sadık; Solak, MustafaAIM: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. RESULTS: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the A and C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). CONCLUSION: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.Öğe Apoptosis and Cerebral Ischemic Reperfusion Injury Developed After Haemorrhagic Shock: Experimental Study(2006) Kalkan, Erdal; Eser, Olcay; Avunduk, Mustafa Cihat; Coşar, Murat; Fidan, Hüseyin; Kalkan, SerpilBACKGROUND: Apoptosis is a process of programmed cell death that plays a role in some normal and pathological conditions. In this study, we investigated the apoptosis during cerebral ischemic reperfusion injury in response to haemorrhagic shock in a rat model. METHODS: Thirty-six adult Sprague-Dawley rats were divided into six groups: control, haemorrhagic shock (HS), ischemic reperfusion (IR), 1st hour IR, 3rd hour IR, 6th hour IR and 24th hour IR. Rats were sacrificed by taking blood from intracardiac area after finishing the experiment. The tissues were fixed using neutral buffered 10% formaldehyde solution for histopathological examination. Tissues were stained immunohistochemically with APO 2.7 and positive expression apoptotic cells were counted using a Clemex Vision Lite 3.5 vision analysis system. RESULTS: There were 2-3 apoptotic cells in the control group (group 1) and this number increased to 8-11 in the haemorrhagic shock group (group 2) (p<0.05). Secondary or more serious injury occurs during ischemic reperfusion injury. The number of apoptotic cells increased to 11-14 at the 1st hour (group 3) and it was significant as compared to group 2 (p<0.05). The number of apoptotic cells significantly increased to 15-17 by the 3rd hour (group 4) as compared to group 3 (p<0.05). While there was no additional increase by the end of the 6th hour (group 5) as compared to group 4, the number of apoptotic cells significantly increased to 18-24 by the end of 24th hour (group 6) as compared to group 5 (p<0.05). CONCLUSION: The majority of injuries to the brain following haemorrhagic shock occur during ischemic reperfusion. We observed that apoptosis increases step by step on the 1st, 3rd and 24th hours after ischemic reperfusion injury.Öğe Association of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes With Degenerative Disc Disease(Mary Ann Liebert Inc, 2010) Eser, Betül; Cora, Tülin; Eser, Olcay; Kalkan, Erdal; Haktanır, Alpay; Erdoğan, Müjgan O.; Solak, MustafaThe aim of this study was to investigate the association between the polymorphisms of the vitamin D receptor (VDR) and aggrecan genes and degenerative disc disease in young Turkish patients. Aggrecan and VDR proteins are the main components of bone and cartilage. In our study, the polymorphisms of the VDR and aggrecan genes were investigated in a total of 300 individuals regarding disc degeneration and herniation. An association was found in the patients having VDR gene TT, Tt, FF, and Ff genotypes with the protrusion type of disc herniation, whereas the patients having tt and ff genotypes were associated with extrusion/sequestration types of the disease. Also, an association was observed between TT and FF genotypes of the VDR gene and mild forms of disc degeneration; and tt, ff, and Ff genotypes and severe forms of the disease. There was also an association between shorter, normal, and longer alleles of the aggrecan gene and a protrusion type of disc herniation. An association was found between short alleles and multilevel and severe disc degeneration, as well as normal and long alleles and mild disc degeneration. This study revealed that the polymorphisms of the VDR and aggrecan genes are associated with disc degeneration and herniation.Öğe Brain tissue biochemical parameters in cerebral ischemic reperfusion injury after hemorrhagic shock: An experimental study(UNIVERSITATSVERLAG ULM GMBH, 2007) Cosar, Murat; Eser, Olcay; Fidan, Hueseyin; Kalkan, Erdal; Buyukbas, Sadik; Ozen, O. A.Objective: In this study, we showed the tissue biochemical parameters in cerebral ischemic reperfusion injury that developed after hemorrhagic shock in a rat model. Materials and Methods: Hemorrhagic shock models were established in 36 adult Sprague-Dawley rats and divided into six groups: control (group A), hemorrhagic shock (HS) (group B), first hour ischemic reperfusion (IR+1h) (group Q, 311 hour IR (IR+3h) (group D), 61(th) hour IR (IR+6h) (group E) and 2411 hour IR (IR+24h) (group F). The rats were sacrificed by bleeding from the intracardiac area after finishing the experiment. The brains were removed from the skull immediately. Bilateral hemispheres were dissected for biochemical analyses, and activities of superoxide dismutase (SOD) and myeloperoxidase (MPO), and the levels of malondialdehyde (MDA) were evaluated. Results: The study revealed that the SOD activities decreased stepwise from group A (control) to group F (IR+24h) (P<0.05). In addition, MDA levels and MPO activities increased stepwise from group A (control) to group F (IR+24h). Conclusion: We think that the level of cell injury increases stepwise in the first, 3(rd), 6(th) and 24(th) hours after ischemia reperfusion injury.Öğe Does Botox effect neural tube development in early chick embryos?(SPRINGER, 2007) Eser, Olcay; Yaman, Mehmet; Cosar, Emine; Konak, Abdullah; Cosar, Murat; Sahin, Oender; Gueney, OenderBotulinum toxin (BTX) is a potent neurotoxin produced by Clostridium botulinum and has wide usage in different areas. The current study aimed to analyze the effects of C. botulinum toxin on the central nerve system in chick embryos. Forty fertile Hubbard Broil eggs, all at Stage 8 of development, were divided into four equal groups: Group 1 embryos (n=10), the control group, were explanted and grown for 18 h in a nutrient medium (thin albumin). Group 2 embryos (n=10) were grown in medium containing 5 U BTX, Group 3 embryos (n=10) in a medium containing 10 U BTX and Group 4 embryos (n=10) in medium containing 20 U BTX. After the incubation period, 80% of Group 1 and 2 embryos and 90% of Group 3 and 4 embryos had intact neural tubes (P > 0.05). The results of this study suggest that BTX had no additional effect on neural tube development in early chick embryos.Öğe The effect of dexmedetomidine in the prefrontal cortex of rabbits after subarachnoidal hemorrhage(UNIVERSITATSVERLAG ULM GMBH, 2006) Eser, Olcay; Cosar, Murat; Fidan, Huseyin; Sahin, Onder; BuyukbaS, Sadik; Ela, Yuksel; Songur, AhmetBackground: This study was undertaken to examine the possible neuroprotective effect of dexmedetomidine in the prefrontal cortex of vasospastic subarachnoid hemorrhage (SAH) rabbits. Materials and Methods: Experimental SAH was performed to the 12 of 18 New Zealand rabbits by injecting 0.9 ml of autologous arterial blood/1 kg of body weight to cisterna magna. Craniotomy procedure was performed to the rest 6 rabbits (control group) (Group A) except performing experimental SAH. Forty eight hours after SAH was established, 5 mL/kg/hour 0.9% sodium chloride were infused to the SAH-alone group (n=6) (Group B) and 5 mu g/kg/h dexmedetomidine were infused to the SAH-dexmedetomidine group (n=6) (Group C) for 2 hours. Rabbits of all groups were sacrificed via penthotal after 24 hours following this drug administration processes. Brains were removed from the skull totally, prefrontal cortices were blocked from the right hemisphere for histopathological study, and prefrontal cortex of left hemispheres were dissected for biochemical analyses. So, malondialdehyde levels, activities of xantine oxidase, and superoxide dismutase were studied from the left prefrontal cortex. Results: The histopathological results showed that dexmedetomidine has neuroprotective effect in SAH induced prefrontal cortex injuries. The antioxidant parameters also supported the neuroprotective effect of dexmedetomidine. Conclusion: The present study showed the neuroprotective effect of dexmedetomidine in the prefrontal cortex of rabbits after vasospastic subarachnoid hemorrhage.Öğe Epidural Thoracal Teratoma in a 7-Month-Old Girl(Springer-Verlag, 2003) Acar, Osman; Güney, Önder; Eser, OlcayCase report: We report a rare case of epidural thoracal teratoma in a 7-month-old girl. A total laminectomy was performed via T6-T8 and the lesion was totally excised. Results and discussion: We describe the radiological, surgical and pathological findings in this patient and review the findings in other reported cases.Öğe The evaluation of protective effects of FK-506 on neural ischemic-reperfusion injury: an experimental study(SPRINGER HEIDELBERG, 2007) Eser, Olcay; Kalkan, Erdal; Cosar, Murat; Yaman, Mehmet; Buyukbas, Sadik; Avunduk, Mustafa Cihat; Fidan, HueseyinObjective: In this study, we aimed to delineate the mode of neuroprotective action of FK-506, and demonstrated that FK-506 could decrease oxidative stress and apoptotic cell death in an in vivo rat model of neural ischemia-reperfusion after hemorrhagic shock. Methods: Thirty rats were used as experimental subjects and divided into five equal groups. Group A rats (sham group, n = 6) were anesthetized and craniotomies were performed for collecting brain tissue samples. In group B ischemia-reperfusion (I/R + 1 h, n = 6), group C (I/R + 24 h, n = 6), group D (I/R + 1 h FK-506, n = 6) and group E (I/R + 24 h FK-506, n = 6), systolic blood pressure of the rats decreased to 40-50% of the normal level via bleeding from the femoral vein. Thus, a hemorrhagic shock and ischemic neural tissue model was formed. The blood was retained and given to the remaining animals in groups B, C, D and E via femoral vein for reperfusion 20 min after the procedure. In group D and E, 1 mg/kg FK-506 in 0.5 ml isotonic solution was administered to the rats 5 min before reperfusion. Group B and D rats were sacrificed after 1 hand group C and E rats were sacrificed 24 h after reperfusion; the rats were sacrificed via bleeding associated with intracardiac puncture. Craniotomy was also performed in groups B, C, D and E and brain tissue samples were fixed using neutral buffered 10% formaldehyde solution for immunohistopathological examination as in group A. Brain tissue superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels, tissue myeloperoxydase (MPO) activities and apoptotic cell analyses with APO 2.7 immunohistochemically were also performed in all groups. Results: The result of the study revealed that the SOD activities were lower for groups B (I/R + 1 h) and C (I/ R + 24 h) than for group A (sham group) (p < 0.05). In addition, SOD activities were higher in groups D (I/ R + 1 h FK-506) and E (I/R + 24 h FK-506) than in groups B (I/R + 1 h) and C (I/R + 24 h) (p < 0.05). MDA levels, MPO activities and the number of apoptotic cells were lower in group A (sham group) than in groups B (I/R + 1 h) and C (I/R + 24 h) (p < 0.05). In addition to these MDA levels, MPO activities and the number of apoptotic cells were higher in groups B (I/R + 1 h) and C (I/R + 24 h) as compared to groups D (I/R + 1 h FK-506) and E (I/R + 24 h FK-506) (p < 0.05). Conclusion: The results suggest that the prophylactic use of FK-506 in an in situ ischemic neural tissue may prevent reperfusion injury.Öğe I?ntraoperatif Periferik Sinir Motor ve Duyu Lif Ayırımında Elektrofizyolojik Yöntem(2003) Üstün, Mehmet Erkan; Güney, Önder; Eser, Olcay; Öğün, Tunç CevatAmaç: Periferik sinir tamiri ve seçici nörotizasyon uygulamalarında motor ve duyu liflerin ayırımı başarıyı önemli derecede artırır. Bu amaçla çeşitli histokimyasal metodlar geliştirilmiş, ancak pratik olmadıklarından yaygınlık kazanamamışlardır. Bu çalışmanın amacı, periferik sinirde duyu ve motor liflerinin elektrofizyolojik olarak ayırt edilebilirliğini deneysel olarak araştırmaktır. Yöntem: Çalışmada, 6 adet tavşanın 12 femoral siniri, motor ve duyu dalları ile birlikte ortaya kondu. Motor ve duyu dalları birbirinden ayrı uyarılarak quadriceps femoris kasından birleşik kas aksiyon potansiyelleri (BKAP) elde edildi. Bulgular: BKAP, motor dalın düşük şiddette uyarımı ile elde edilebilirken, duyu dalının ancak çok yüksek şiddette uyarımları ile oluşturulabildi. Yüksek şiddette uyarının antidromik yolla spinal korda ve oradan ön boynuz motor nöronlarına geçerek BKAP'ni ortaya çıkardığı düşünüldü. Sonuç: Sonuç olarak, BKAP'ni kullanarak motor ve duyu lif ayırımı yapmak mümkündür. Bu yöntem ucuz, kolay ve çok hızlı olması nedeniyle, sinir transferi ve primer sinir tamiri olgularında diğer zaman aNcı tekniklerin yerine veya onlara yardımcı olarak kullanılabilir.Öğe The influence of dexmedetomidine on ischemic rat hippocampus(ELSEVIER SCIENCE BV, 2008) Eser, Olcay; Fidan, Huseyin; Sahin, Onder; Cosar, Murat; Yaman, Mehmet; Mollaoglu, Hakan; Songur, AhmetIn our study, we evaluated the neuroprotective effects of dexmedetomidine on oxidantantioxidant systems, pro -inflammatory cytokine TNF-a and number of apoptotic neurons on hippocampus and dentate gyrus after transient global cerebral I/R injury. Eighteen rats divided into 3 groups, equally. Group I rats were used as shams. For group II and III rats, they were prepared for transient global cerebral ischemia using a four-vessel- occlusion model. 5 mL/kg/h 0.9% sodium chloride was infused to the Group II and 3 Pg/kg/h/5 ml dexmedetomidine was infused to the Group III for 2 h after I/R injury. The levels of MDA and NO and activities of SOD and CAT were measured in the left hippocampus tissue. The levels of TNF-a concentration were measured in the plasma. The number of apoptotic neurons was counted by TUNNEL method in histological samples of right hippocampus tissue. MDA and NO levels increased in Group II compared with Group I rats (p=0.002, p=0.002, respectively). In group III, MDA and NO levels decreased as compared to Group 11 (p=0.015, p=0.002, respectively). SOD and CAT activities increased in Group III as compared to Group II rats (p = 0.002, p = 0.002, respectively). The decrease in TNF-a levels of group III was significant as compared to group II (p=0.016). The number of apoptotic neurons in group III was lower than Group II rats. Our study showed that dexinedetomidine has a neuroprotective effect on hippocampus and dentate gyrus of rats after transient global cerebral I/R injury. (c) 2008 Elsevier B.V. All rights reserved.Öğe Kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures: Case report(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanThe aim of the kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures in geriatric patients is to improve the patient's quality of life. In this report we present two elderly patients who were suffering of traumatic osteoporotic vertebral compression fractures and underwent successful kyphoplasties. Percutaneous kyphoplasty method for the surgical treatment of these fractures decreases the hospitalization, morbidity and mortality in these patients.Öğe The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage(ELSEVIER SCIENCE INC, 2009) Cosar, Murat; Eser, Olcay; Fidan, Huseyin; Sahin, Onder; Buyukbas, Sadik; Ela, Yuksel; Yagmurca, MuratBackground: Subarachnoid hemorrhage is a Serious Condition. often accompanied by cerebral vasospasm. which may lead to brain ischemia and neurologic deterioration. We evaluated if dexmedetomidine has neuroprotective effects in the hippocampus of vasospastic SAH rabbits or not. Materials and Methods: Eighteen New Zealand rabbits were taken. Ail experimental SAH model was Formed by injecting 0.9 mL of autologous arterial blood per 1 kg of body weight to the cisterna magna of 12 rabbits. Craniotomy was performed ill the control group (n = 6) except performing experimental SAH. Rabbits in the SAH-alone (n = 6) group were infused with 5 mL . kg(-1) . h(-1) 0.9% sodium chloride, and rabbits (n = 6) in the SAH-dexmedetomidine group were infused with 5 mu g . kg(-1) . h(-1) dexmedetomidine for 2 hours, 48 hours alter SAH was established. Rabbits of all groups were sacrificed via penthotal 24 hours after dexmedetomidine administration. Brains were removed immediately. and hippocampal tissues were blocked from the right hemisphere for histopathologic study. In addition to this, hippocampal tissues of left hemispheres were dissected for biochemical analyses to evaluate MDA levels, activity of XO, and SOD. Results: The histopathologic study showed that dexmedetomidine may have a neuroprotective effect in SAH-induced hippocampal injuries. The biochemical parameters Support the neuroprotective effect of dexmedetomidine (P < .05). Conclusion: Our Study showed that dexmedetomidine may have a neuroprotective effect ill the hippocampus of vasospastic SAH rabbits. (C) 2009 Elsevier Inc. All rights reserved.Öğe A new reversible ischemic neurologic deficit model in dogs(INT SCIENTIFIC INFORMATION, INC, 2008) Oeguen, Cemile Oeztin; Tastekin, Guengoer; Kiresi, Demet; Eser, Olcay; Uestuen, Mehmeet ErkanBackground: The aim of this study was to produce an internal carotid artery (ICA) occlusion model in dogs that can be used for studying the effects of surgical revascularization procedures. Material/Methods: After left frontoparictal craniectomy, the ICA and arterial circle of the brain were coagulated and transected, letting the middle cerebral artery be perfused by the contralateral ICA by way of the rostral cerebral artery in five mongrel dogs. Magnetic resonance imaging (MRI) and brain single-photon emission computed tomography (SPECT) were performed during the first 24 to 48 hours and 7 to 10 days after the operation. Paired t and Wilcoxon matched pair tests were used for statistics (p < 0.05). Results: All the dogs had postoperative hemiparesis that returned to normal after 7 to 10 days. Early MRI showed cerebral ischemia in the left parietal cortical area extending to the subcortical white matter, sparing the basal ganglion and the internal capsule. Early brain SPECT demonstrated hypoperfusion corresponding to the same area. This area became significantly restricted to a small cortical area in late MRI and SPECT images (p < 0.05). Conclusions: It is conlcuded that, as symptoms resolved spontaneously, this model can be used as a "reversible ischemic neurological deficit" model for diagnostic imaging and pharmacological studies.Öğe The Penetration of Cefoperazone and Sulbactam Into the Lumbar Intervertebral Discs(LIPPINCOTT WILLIAMS & WILKINS, 2001) Köroğlu, Adnan; Acar, Osman; Üstün, Mehmet Erkan; Tıraş, Bünyamin; Eser, OlcaySix patients received I and six other patients received 2 of cefoperazone and sulbactam 15 minutes before lumbar disc surgery. Liquid chromatographic analysis of disc tissue revealed that only patients receiving the 2-g dose had mean tissue levels above the minimum inhibitory concentration for Staphylococcus aureus and epidermidis.Öğe The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex(TAYLOR & FRANCIS LTD, 2011) Eser, Olcay; Songur, Ahmet; Yaman, Mehmet; Cosar, Murat; Fidan, Huseyin; Sahin, Onder; Mollaoglu, HakanObject. We investigated the protective effects of avocado/soybean unsaponifiables (ASU) on the prefrontal cortex (PFC) after global brain ischemia/reperfusion (I/R) injury in rats. Methods. Rats were randomly divided into three experimental groups as follows: Group I was control rats, Group II was ischemia rats, Group III was Isch+ASU rats. Brain ischemia was produced via four-vessel occlusion model. These processes followed by reperfusion for 30 min for both II and III groups. Rats were sacrificed and their brains were removed immediately. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in left PFC, levels of TNF-alpha concentration were measured in the plasma. The number of apoptotic neurons was assayed in histological samples of the right PFC. Results. MDA and TNF-alpha levels as well as the number of apoptotic neurons were observed to have decreased significantly in Group III compared to Group II, while SOD activities have been found to have increased significantly in Group III in comparison to Group II, significantly. Conclusions. We think that ASU might have an antioxidant and neuroprotective effects in brain I/R injured rats.Öğe Spect'i?n I?skemi?k Ti?pte Stroktaki? Prognosti?k Değeri?(2002) Üstün, Erkan M.; Yürüten, Betigül; Taştekin, Güngür; Atçı, Arzu; Eser, OlcayPurpose and method: In order to evaluate the prognostic value of SPECT (single photon emission computed tomography) in ischemic stroke patients, we reviewed the neurological examinations, CT (computed tomography), MRI (magnetic rezonance imaging) and SPECT scans of 42 stroke patients which are performed between 1998 and 2000. All SPECT scans had been performed after 72 hours. 34 patients came back for control neurological examination. The mean time interval between the SPECT evaluation and control neurological examination was 10 months (ranging between 4 to 24 months). Results: The 87.5% of patients that had perfusion defect above 60% had severe motor deficit and 78.9% of these patients could not recover. Conversely 88.9% of the patients that had perfusion defect below 60% (mild to moderate) had mild or moderate motor deficit and 80% of these patients exhibited good recovery. All of the patients with severe hypoperfusion had positive findings in radiological examination while 73.7% of the patients with mild to moderate hypoperfusion had positive findings. Conclusion: SPECT findings showed good correlation with neurological status and prognosis. The ischemic lesions which can not seen in CT and MRI examination, can be detected by SPECT.Öğe Spect'in İskemik Tipte Stroktaki Prognostik Değeri(2002) Üstün, Mehmet Erkan; Yürüten, Betigül; Taştekin, Güngür; Atcı, Arzu; Eser, OlcayAmaç: SPECT'in (single photon emission computed tomography) iskemik stroktaki prognostik değerini tayin etmek amacı ile 1998-2000 yılları arasında geçirilmiş strok nedeniyle motor defisiti olan 42 hastada strok'tan 72 saat sonra BT (Bilgisayarlı Tomografi) ve/veya MRG (magnetik rezonans görüntüleme) yanısıra SPECT incelemesi yapıldı. Gereç ve Yöntem: Hastalardan 34'ünün 4 ay ile 24 ay arasında değişen sürelerde (ortalama 10 ay) kontrol motor muayeneleri yapıldı. SPECT bulgularının hem nörolojik tablo, hem BT ve/veya MRG bulguları ile hem de takibi yapılan hastalarda prognoz ile olan ilişkisine bakıldı. Bulgular: SPECT'te ileri hipoperfüzyon (%60'ın üzerinde perfüzyon kaybı) gözlenen vakaların %87.5'inde ileri motor defisit olduğu ve bu defisitin hastaların %78.9'unda düzelmediği, buna karşı hafif-orta hipoperfüzyon (%60 ve altında perfüzyon kaybı) varsa hastaların %88.9'unda orta veya hafif motor defisiti olduğu ve hastaların %80'inin fonksiyonel olarak düzeldiği görüldü. SPECT'de ileri hipoperfüzyonu olan hastaların hepsinde BT ve/veya MRG'de infarkt görülürken, hafif-orta hipoperfüzyonu olan hastalarda bu oran %73.7'ye düşmekteydi. Sonuç: SPECT bulguları ile nörolojik tablonun korelasyon gösterdiği, radyolojik görüntüleme yöntemleriyle saptanamayan lezyonların SPECT ile gösterilebileceği ve SPECT'in prognozu belirlemede önemli bir tanı yöntemi olduğu kanaatine varıldı.Öğe The Split Notocord Syndrome with Meningocele and Diastematomyelia(2001) Üstün, Mehmet Erkan; Köroğlu, Adnan; Canbilen, Aydan; Avunduk, Mustafa Cihat; Güney, Önder; Eser, Olcay; Konuk, AbdullahMeningosel ve diastomatomiyeli ile birlikte olan lumbosakral vertebra yerleşimli, split notokord sendromu oldukça ender görülen konjenital bir anomalidir. Bu olgu literatürde dorsal enterik açıklığı olmayan beşinci olgudur. Embriyolojik gelişimi henüz tam olarak anlaşılamayan bu tür olgular literatürlerin eşliğinde tartışıldı.Öğe Submandibular and Intracranial Hydatid Cyst in an Adolescent(Lippincott Williams & Wilkins, 2002) Güney, Önder; Öztürk, Kayhan; Kocaoğullar, Yalçın; Eser, Olcay; Acar, OsmanObjectives: An unusual case of hydatid disease is reported. Review of the pertinent literature did not reveal any hydatid disease located simultaneously in both the intracranial and submandibular glands. This is the first case with hydatid disease occurring in both locations at the same time. Study Design: The case of an 18-year-old is presented; the symptoms, findings, methods of diagnosis, and our approach for treatment are discussed; and the literature is reviewed. Results. The intracranial lesion was completely excised by left-sided frontoparietal craniotomy, and the mass in the right side of the submandibular gland was removed through a submandibular approach at the same session. The intact cyst was completely excised. Histological examination of both lesions confirmed the diagnosis of hydatid cyst by Echinococcus granulosus. Postoperative recovery was uneventful, and the patient was discharged on the seventh day. Conclusions. Hydatid cyst should be suspected during the evaluation of cervical masses, particularly in endemic regions. Hydatid disease infestations are best treated with complete excision of the intact cyst.Öğe Travmaya Bağlı Osteoporotik Vertebra Çökme Kırıklarının Tedavisinde Kifoplasti Uygulaması: Olgu Sunumu(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanYaşlılarda travmaya bağlı oluşan osteoporotik vertebra çökme kırıklarının tedavisinde uygulanan kifoplasti yöntemiyle hastaların yaşam kalitesinin arttırılması amaçlanmıştır. Bu yazıda travmatik osteoporotik vertebra çökme kırığı nedeniyle başvuran ve tedavilerinde başarıyla kifoplasti ameliyatı uygulanan iki yaşlı hastanın özellikleri ve sonuçları sunuldu. Osteoporotik vertebra çökme kırıklarının cerrahi tedavisinde perkütan olarak uygulanan kifoplasti, hastaların hastanede kalış sürelerini kısaltmakta, morbidite ve mortalitesini önemli derece azaltmaktadır.
