Serum and cord blood-methylated arginine levels in gestational diabetic subjects
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WALTER DE GRUYTER GMBH
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: Micro- and macrovascular endothelial deterioration has been mentioned in diabetic pregnants with critical clinical outcome for the fetus. Our aim was to measure serum and cord blood concentrations of methylated arginines in patients with gestational diabetes and find a relationship with endothelial dysfunction. Materials and methods: Methylated arginines were detected with high performance liquid chromatography mass spectrometry via electrospray ionization positive technique with a chromatographic C18 column. Results: Although gestational diabetes mellitus (GDM) groups' asymmetric dimethylarginine (ADMA) levels were higher compared to control group, this difference was not significant. Control cord blood ADMA and N-monomethy-larginine levels were significantly higher than insulin-regulated GDM cord blood ADMA and N-monomethylarginine levels (p = 0.001; p= 0.003, respectively). Diet-regulated GDM group's cord blood N-monomethylarginine was significantly higher than insulin-regulated GDM group's cord blood N-monomethylarginine (p= 0.045). A negative correlation was found between cord blood symmetric dimethylarginine and oral glucose tolerance testing Oh glucose values (r = -0.453, p = 0.002). Conclusions: According to this study's results, methylated arginine levels may not be associated with endothelial deterioration in GDM otherwise with preeclampsia risk.
Açıklama
Anahtar Kelimeler
Methylated arginines, Gestational diabetes, impaired glucose tolerance, Tandem mass spectrometry, Endothelial dysfunction
Kaynak
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
44
Sayı
2
Künye
Yıldırımkaya, M., Abusoglu, S., Yilmaz, S. A., Saracligil, B., Hataysal, E. P., Ecer, B., Unlu, A. (2019). Serum and Cord Blood-Methylated Arginine Levels in Gestational Diabetic Subjects. Turkish Journal of Biochemistry, 44(2), 153-160.
