Serum and cord blood-methylated arginine levels in gestational diabetic subjects

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dc.contributor.authorYıldırımkaya, Metin
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorYılmaz, Setenay Arzu
dc.contributor.authorSaraçlıgil, Beyza
dc.contributor.authorHataysal, Esra Paydaş
dc.contributor.authorEcer, Büşra
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T20:19:17Z
dc.date.available2020-03-26T20:19:17Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Micro- and macrovascular endothelial deterioration has been mentioned in diabetic pregnants with critical clinical outcome for the fetus. Our aim was to measure serum and cord blood concentrations of methylated arginines in patients with gestational diabetes and find a relationship with endothelial dysfunction. Materials and methods: Methylated arginines were detected with high performance liquid chromatography mass spectrometry via electrospray ionization positive technique with a chromatographic C18 column. Results: Although gestational diabetes mellitus (GDM) groups' asymmetric dimethylarginine (ADMA) levels were higher compared to control group, this difference was not significant. Control cord blood ADMA and N-monomethy-larginine levels were significantly higher than insulin-regulated GDM cord blood ADMA and N-monomethylarginine levels (p = 0.001; p= 0.003, respectively). Diet-regulated GDM group's cord blood N-monomethylarginine was significantly higher than insulin-regulated GDM group's cord blood N-monomethylarginine (p= 0.045). A negative correlation was found between cord blood symmetric dimethylarginine and oral glucose tolerance testing Oh glucose values (r = -0.453, p = 0.002). Conclusions: According to this study's results, methylated arginine levels may not be associated with endothelial deterioration in GDM otherwise with preeclampsia risk.en_US
dc.identifier.citationYıldırımkaya, M., Abusoglu, S., Yilmaz, S. A., Saracligil, B., Hataysal, E. P., Ecer, B., Unlu, A. (2019). Serum and Cord Blood-Methylated Arginine Levels in Gestational Diabetic Subjects. Turkish Journal of Biochemistry, 44(2), 153-160.
dc.identifier.doi10.1515/tjb-2018-0201en_US
dc.identifier.endpage160en_US
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://dx.doi.org/10.1515/tjb-2018-0201
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38192
dc.identifier.volume44en_US
dc.identifier.wosWOS:000473280800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorYılmaz, Setenay Arzu
dc.institutionauthorHataysal, Esra Paydaş
dc.institutionauthorEcer, Büşra
dc.institutionauthorÜnlü, Ali
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMethylated argininesen_US
dc.subjectGestational diabetesen_US
dc.subjectimpaired glucose toleranceen_US
dc.subjectTandem mass spectrometryen_US
dc.subjectEndothelial dysfunctionen_US
dc.titleSerum and cord blood-methylated arginine levels in gestational diabetic subjectsen_US
dc.typeArticleen_US

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