Chromosome 8 Aneuploidy in Acquired Cholesteatoma

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dc.contributor.authorYıldırım, Mahmut Selman
dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorAcar, Hasan
dc.contributor.authorArbağ, Hamdi
dc.contributor.authorÜlkü, Çağatay Han
dc.date.accessioned2020-03-26T16:45:30Z
dc.date.available2020-03-26T16:45:30Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective-To investigate the incidence of chromosome 8 aneuploidy in acquired cholesteatoma. Material and methods-Cholesteatoma tissue and postauricular skin as a control were surgically obtained from 12 patients with acquired cholesteatoma. Fluorescence in situ hybridization (FISH) analysis using a chromosome 8-specific alpha-satellite DNA probe was performed on the interphase nuclei. Two hundred cells were analyzed for each of the samples. Results-Chromosome 8 aneuploidy was found in 9/12 patients whereas a normal cell structure with 2 signals was observed in the remaining 3 patients. In samples with chromosome 8 aneuploidy, the mean proportion of aneuploidy was 25.6%, including monosomy (3.2%), trisomy (16.1%), tetrasomy (4.9%) and more than tetrasomy (1.4%). The number of aneuploid cells in recurrent cases was more than that in non-recurrent cases. Conclusions-A numerical aberration of chromosome 8 was found in patients with acquired cholesteatoma. Our results support the hypothesis that chromosome 8 may be a prognostic factor for cholesteatoma and an indicator in the follow-up of patients with cholesteatoma.en_US
dc.identifier.citationYıldırım, M. S., Öztürk, K., Acar, H., Arbağ, H., Ülkü, C. H., (2003). Chromosome 8 Aneuploidy in Acquired Cholesteatoma. Acta Oto-Laryngologica, 123(3), 372-376. Doi: 10.1080/00016480310001286
dc.identifier.doi10.1080/00016480310001286en_US
dc.identifier.endpage376en_US
dc.identifier.issn0001-6489en_US
dc.identifier.issue3en_US
dc.identifier.pmid12737293en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage372en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00016480310001286
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18392
dc.identifier.volume123en_US
dc.identifier.wosWOS:000182665700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYıldırım, Mahmut Selman
dc.institutionauthorÖztürk, Kayhan
dc.institutionauthorAcar, Hasan
dc.institutionauthorArbağ, Hamdi
dc.institutionauthorÜlkü, Çağatay Han
dc.language.isoenen_US
dc.publisherTaylor & Francis asen_US
dc.relation.ispartofActa Oto-Laryngologica en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCholesteatomaen_US
dc.subjectChromosome 8en_US
dc.subjectFluorescence in Situ Hybridizationen_US
dc.subjectLocalizationen_US
dc.subjectRecurrenceen_US
dc.titleChromosome 8 Aneuploidy in Acquired Cholesteatomaen_US
dc.typeArticleen_US

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