Intraoperative determination of intestinal viability: A comparison with transserosal pulse oximetry and histopathological examination
Yükleniyor...
Dosyalar
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACADEMIC PRESS INC ELSEVIER SCIENCE
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. In this study, we aimed to measure the O-2 saturation of ischemic intestinal segments and the relationship between these measures and concomitant pathological gradings. Materials and methods. We used 14 New Zealand White rabbits, anesthetized with a combination of 80 mg/kg (i.m.) Ketamine hydrochloride and 10 mg/kg Acepromazine (i.m.). The superior mesenteric artery (SMA) was explored, and O-2 saturation was measured by pulse oximetry 5 cm proximal to the ileocecal valve at the 0th hour. At the same time a 0.5-cm. full-thickness wedge biopsy was taken from the same region. Thereafter, the SMA was ligated and the abdomen was closed. All rabbits were undertaken relaparotomy at the 4th hour; O-2 saturation was measured by pulse oximetry at 5 cm away from the region of the first biopsy and a 0.5-cm. full-thickness wedge biopsy was taken. The abdomen was then closed. The same procedure was performed at the 8th and the 12th hour. Mucosal hemorrhage, transmural congestion, mucosal necrosis, and transmural necrosis were examined in the specimens. Results. Pathologically, transmural necrosis was concomitant with 64% O-2 saturation (sensitivity: 100%; specificity: 86%). Mucosal necrosis was concomitant with 76% O-2 saturation values (sensitivity: 100%; specificity: 75%). Transmural congestion was concomitant with 81% O-2 saturation values (sensitivity: 89%; specificity: 58%). Mucosal hemorrhage was concomitant with 91% O-2 saturation (sensitivity: 100%; specificity: 31%). Conclusion. O-2 saturation measures > 76% may indicate reversible changes as mucosal necrosis, transmural congestion, or mucosal hemorrhage, and O-2 saturation measures < 64% may indicate permanent transmural necrosis. As a result, intraoperative evaluation of intestinal viability by pulse oximetry may give us an idea about the degree of pathological changes and subsequently might reduce the number of second-look operations. (c) 2005 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
intestinal ischemia, pulse oximetry, oxygen saturation, intestinal viability, histopathological examination
Kaynak
JOURNAL OF SURGICAL RESEARCH
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
128
Sayı
1
