Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictors of type 2 diabetes among nonobese diabetics in the Turkish population

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dc.contributor.authorErkoc Kaya, Dudu
dc.contributor.authorArikoglu, Hilal
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorOzturk, Onur
dc.contributor.authorGonen, Mustafa Sait
dc.date.accessioned2020-03-26T19:43:17Z
dc.date.available2020-03-26T19:43:17Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods: Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results: We found that rs7903146 C -> T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G -> T substitution in intron 4 (OR: 2.1, P = 0.002) were significantly associated with T2D while other SNPs were not associated (P > 0.05). We determined no association between TCF7L2 gene polymorphisms and fasting glucose, fasting insulin, HbA1c, or HOMA-IR levels (P > 0.05), except for rs7903146 C -> T substitution, which was significantly associated with the fasting glucose level (P = 0.003). Conclusion: Our results indicate that, in the Turkish population, the T allele of the rs7903146 (C -> T) and rs12255372 (G -> T) polymorphisms in the TCF7L2 gene is an independent risk factor for the development of T2D.en_US
dc.description.sponsorshipSelcuk University Research FoundationSelcuk University [09202048]en_US
dc.description.sponsorshipWe would like to thank Dr Hulya Ozdemir and Dr Suleyman Hilmi Ipekci for their assistance in this study. This study was supported by the Selcuk University Research Foundation (09202048).en_US
dc.identifier.doi10.3906/sag-1507-160en_US
dc.identifier.endpage28en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue1en_US
dc.identifier.pmid28263491en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1507-160
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35641
dc.identifier.volume47en_US
dc.identifier.wosWOS:000395632600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectTCF7L2 geneen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subjectWnt pathwayen_US
dc.titleTranscription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictors of type 2 diabetes among nonobese diabetics in the Turkish populationen_US
dc.typeArticleen_US

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