Evaluation of Relationship Between Chromosome 22 and p53 Gene Alterations and the Subtype of Meningiomas by the Interphase-Fish Technique
Yükleniyor...
Dosyalar
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-liss
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, we investigated the relationship between genetic alterations such as chromosome 22 aneuploidy and p53 gene deletion, and the pathological types of meningioma of typical and aggressive forms. Thirty-four meningiomas (23 typical and 11 aggressive) were examined by application of fluorescence in situ hybridization (FISH) with chromosome 22 specific alpha satellite probe and a combination of p53 locus specific and chromosome 17 centromere specific alpha satellite probes, to evaluate the chromosome 22 aneuploidy and gain or loss of p53 gene along with chromosome 17. The results showed that, although chromosome 22 aneuploidy was seen in 7 out of 23 typical (30.4%) and 4 out of 11 aggressive meningiomas (36.3%), no p53 deletion was detected in typical meningiomas, and p53 deletion was detected in 3 out of 11 aggressive meningiomas (1 atypical and 2 malignant), which had recurrence. There were no simultaneous occurrences of p53 gene deletions between typical and aggressive meningiomas. The present findings indicate that the loss of chromosome 22 may be involved with tumorogenesis of typical and aggressive meningiomas, while p53 gene deletions may be involved with malignant progression and recurrence in the aggressive meningiomas.
Açıklama
Anahtar Kelimeler
meningioma, FISH, chromosome 22, p53 gene
Kaynak
Teratogenesis Carcinogenesis and Mutagenesis
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
22
Sayı
Künye
Yakut, T., Bekar, A., Doygun, M., Acar, H., Egeli, Ü., Oğul, E., (2002). Evaluation of Relationship Between Chromosome 22 and p53 Gene Alterations and the Subtype of Meningiomas by the Interphase-Fish Technique. Teratogenesis Carcinogenesis and Mutagenesis, (22), 217-225. Doi: 10.1002/tcm.10013
