Evaluation of Relationship Between Chromosome 22 and p53 Gene Alterations and the Subtype of Meningiomas by the Interphase-Fish Technique

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dc.contributor.authorYakut, Tahsin
dc.contributor.authorBekar, Ahmet
dc.contributor.authorDoygun, Muammer
dc.contributor.authorAcar, Hasan
dc.contributor.authorEgeli, Ünal
dc.contributor.authorOğul, Erhan
dc.date.accessioned2020-03-26T16:39:04Z
dc.date.available2020-03-26T16:39:04Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, we investigated the relationship between genetic alterations such as chromosome 22 aneuploidy and p53 gene deletion, and the pathological types of meningioma of typical and aggressive forms. Thirty-four meningiomas (23 typical and 11 aggressive) were examined by application of fluorescence in situ hybridization (FISH) with chromosome 22 specific alpha satellite probe and a combination of p53 locus specific and chromosome 17 centromere specific alpha satellite probes, to evaluate the chromosome 22 aneuploidy and gain or loss of p53 gene along with chromosome 17. The results showed that, although chromosome 22 aneuploidy was seen in 7 out of 23 typical (30.4%) and 4 out of 11 aggressive meningiomas (36.3%), no p53 deletion was detected in typical meningiomas, and p53 deletion was detected in 3 out of 11 aggressive meningiomas (1 atypical and 2 malignant), which had recurrence. There were no simultaneous occurrences of p53 gene deletions between typical and aggressive meningiomas. The present findings indicate that the loss of chromosome 22 may be involved with tumorogenesis of typical and aggressive meningiomas, while p53 gene deletions may be involved with malignant progression and recurrence in the aggressive meningiomas.en_US
dc.identifier.citationYakut, T., Bekar, A., Doygun, M., Acar, H., Egeli, Ü., Oğul, E., (2002). Evaluation of Relationship Between Chromosome 22 and p53 Gene Alterations and the Subtype of Meningiomas by the Interphase-Fish Technique. Teratogenesis Carcinogenesis and Mutagenesis, (22), 217-225. Doi: 10.1002/tcm.10013
dc.identifier.doi10.1002/tcm.10013en_US
dc.identifier.endpage225en_US
dc.identifier.issn0270-3211en_US
dc.identifier.pmid11948632en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://dx.doi.org/10.1002/tcm.10013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17955
dc.identifier.volume22en_US
dc.identifier.wosWOS:000175234800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.language.isoenen_US
dc.publisherWiley-lissen_US
dc.relation.ispartofTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmeningiomaen_US
dc.subjectFISHen_US
dc.subjectchromosome 22en_US
dc.subjectp53 geneen_US
dc.titleEvaluation of Relationship Between Chromosome 22 and p53 Gene Alterations and the Subtype of Meningiomas by the Interphase-Fish Techniqueen_US
dc.typeArticleen_US

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