HLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey

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dc.contributor.authorOzgenel, Safak Meric
dc.contributor.authorTemel, Tuncer
dc.contributor.authorTeke, Hava Uskudar
dc.contributor.authorYildiz, Pinar
dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorOzakyol, Aysegul
dc.date.accessioned2020-03-26T20:14:30Z
dc.date.available2020-03-26T20:14:30Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, İç Hastalıkları Bölümüen_US
dc.description.abstractBackground/Aims: Celiac disease is an autoimmune, familial disease that results in susceptibility to gluten in cereal and cereal products in genetically susceptible individuals. The aim of the present study was to investigate the presence of HLA-DQ2/DQ8 in patients with celiac disease, their first-degree relatives, and healthy community. Materials and Methods: HLA-DQ2/DQ8 analysis was performed in adult patients with celiac disease >= 18 years old (94 patients), their first-degree relatives (89 people), and healthy group (102 individuals). Anemia, osteoporosis, and diarrhea were interrogated in the celiac patient group and also anti-tissue transglutaminase, anti-endomysium, and anti-gliadin antibodies were recorded. Results: There was a significant relationship between HLA-DQ2/DQ8 presence in all groups, and the distribution of HLA-DQ2/DQ8 in all groups was different (p=0.000). No statistically significant correlation was found between the HLA tissue groups and diarrhea (p=0.087), osteoporosis (p=0.215), anemia (p=1.000), tissue transglutaminase antibodies (p=0.295), anti-gliadin antibodies (p=0.104), and anti -endomysium antibodies (p=0.243) in the celiac patient group. Conclusion: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degree relatives.en_US
dc.description.sponsorshipEskisehir Osmangazi University Scientific Research Project Funden_US
dc.description.sponsorshipThe authors declared that this study has received financial support from the Eskisehir Osmangazi University Scientific Research Project Fund.en_US
dc.identifier.citationOzgenel S.M., Temel T., Teke H. U., Yıldız P., Korkmaz H., Ozakyol A. (2019). HLA-DQ2/DQ8 Frequency in Adult Patients with Celiac Disease, their First-degree relatives, and Normal Population in Turkey. Türkish Journal of Gastroenterology, 30(1), 321-325.
dc.identifier.doi10.5152/tjg.2019.18255en_US
dc.identifier.endpage325en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issn2148-5607en_US
dc.identifier.issue4en_US
dc.identifier.pmid30945642en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://dx.doi.org/10.5152/tjg.2019.18255
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37890
dc.identifier.volume30en_US
dc.identifier.wosWOS:000463369400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Huseyin
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCeliac diseaseen_US
dc.subjectHLA DQ2en_US
dc.subjectHLA DQ8en_US
dc.subjectTurkish populationen_US
dc.titleHLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkeyen_US
dc.typeArticleen_US

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