Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Dexmedetomidine is a selective alpha 2-adrenoceptor agonist that is used because of its sedative, anxiolytic, and analgesic effects. Dexketoprofen, which is used as an analgesic, is a nonselective nonsteroidal anti-inflammatory drug (NSAID). The use of dexmedetomidine and dexketoprofen as adjuvants to local anesthetics for the peripheral nerve is gradually increasing. In this study, we aimed to investigate the effects of different doses of dexmedetomidine and dexketoprofen on conduction block of rat sciatic nerve. The isolated sciatic nerve from adult rats was transferred to a nerve chamber. The compound action potentials (CAPs) were recorded from stimulated nerve with electrophysiological methods. Dexmedetomidine (n = 8) and dexketoprofen (n = 8) were administered in the chamber with cumulative concentrations of 10-9 to 10-5 M, and the CAPs were recorded for 5 and 10 minutes. The CAP parameters were calculated. Both dexmedetomidine and dexketoprofen significantly depressed all CAP parameters in a dose-dependent manner compared with the control group, i.e., the group in which rats did not receive treatment. CAP parameters showed there was no significant difference in nerve conduction inhibition between dexmedetomidine and dexketoprofen. Higher doses of dexmedetomidine suppressed the conduction in the fast-conducting fibers; however, dexketoprofen was found to suppress the conduction in the slow-conducting fibers in a time-dependent manner and suppress the conduction in the medium- and slow-conducting fibers in a dose-dependent manner. These findings suggest that dexmedetomidine and dexketoprofen exhibit better anesthetic effects on peripheral nerve through different ways of action. The experimental procedures were approved by the Necmettin Erbakan University on January 30, 2013 (approval No. 2013-024).
Açıklama
Anahtar Kelimeler
compound action potentials, dexketoprofen, dexmedetomidine, maximum depolarization, nerve chamber, nerve fibers, sciatic nerve
Kaynak
NEURAL REGENERATION RESEARCH
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
15
Sayı
5
Künye
Taylan, S. B., Bariskaner, H. (2020). Effects of Dexmedetomidine and Dexketoprofen on the Conduction Block of Rat Sciatic Nerve. Neural Regeneration Research, 15(5), 929-935.
