Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve

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dc.authorid0000-0002-8158-4487
dc.contributor.authorTaylan, Sengal Bagci.
dc.contributor.authorBariskaner, Hulagu.
dc.date.accessioned2020-03-26T20:20:14Z
dc.date.available2020-03-26T20:20:14Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractDexmedetomidine is a selective alpha 2-adrenoceptor agonist that is used because of its sedative, anxiolytic, and analgesic effects. Dexketoprofen, which is used as an analgesic, is a nonselective nonsteroidal anti-inflammatory drug (NSAID). The use of dexmedetomidine and dexketoprofen as adjuvants to local anesthetics for the peripheral nerve is gradually increasing. In this study, we aimed to investigate the effects of different doses of dexmedetomidine and dexketoprofen on conduction block of rat sciatic nerve. The isolated sciatic nerve from adult rats was transferred to a nerve chamber. The compound action potentials (CAPs) were recorded from stimulated nerve with electrophysiological methods. Dexmedetomidine (n = 8) and dexketoprofen (n = 8) were administered in the chamber with cumulative concentrations of 10-9 to 10-5 M, and the CAPs were recorded for 5 and 10 minutes. The CAP parameters were calculated. Both dexmedetomidine and dexketoprofen significantly depressed all CAP parameters in a dose-dependent manner compared with the control group, i.e., the group in which rats did not receive treatment. CAP parameters showed there was no significant difference in nerve conduction inhibition between dexmedetomidine and dexketoprofen. Higher doses of dexmedetomidine suppressed the conduction in the fast-conducting fibers; however, dexketoprofen was found to suppress the conduction in the slow-conducting fibers in a time-dependent manner and suppress the conduction in the medium- and slow-conducting fibers in a dose-dependent manner. These findings suggest that dexmedetomidine and dexketoprofen exhibit better anesthetic effects on peripheral nerve through different ways of action. The experimental procedures were approved by the Necmettin Erbakan University on January 30, 2013 (approval No. 2013-024).en_US
dc.description.sponsorshipScientific Committee Foundation of Selcuk University, Konya, TurkeySelcuk University [13102007]en_US
dc.description.sponsorshipThis study was supported by Scientific Committee Foundation (No. 13102007) of Selcuk University, Konya, Turkey (to HB).en_US
dc.identifier.citationTaylan, S. B., Bariskaner, H. (2020). Effects of Dexmedetomidine and Dexketoprofen on the Conduction Block of Rat Sciatic Nerve. Neural Regeneration Research, 15(5), 929-935.
dc.identifier.doi10.4103/1673-5374.268926en_US
dc.identifier.endpage935en_US
dc.identifier.issn1673-5374en_US
dc.identifier.issn1876-7958en_US
dc.identifier.issue5en_US
dc.identifier.pmid31719259en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage929en_US
dc.identifier.urihttps://dx.doi.org/10.4103/1673-5374.268926
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38537
dc.identifier.volume15en_US
dc.identifier.wosWOS:000507630200024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBariskaner, Hulagu.
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofNEURAL REGENERATION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcompound action potentials
dc.subjectdexketoprofen
dc.subjectdexmedetomidine
dc.subjectmaximum depolarization
dc.subjectnerve chamber
dc.subjectnerve fibers
dc.subjectsciatic nerve
dc.titleEffects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerveen_US
dc.typeArticleen_US

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