Role of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Cooling
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PHARMACEUTICAL SOC JAPAN
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In the present study, the effects of cooling (to 28 degrees C) on the vasodilatation induced by diazoxide (10(-9)-3x 10(-4) M), isoproterenol (10(-9)-3x 10(-4) M) and magnesium sulphate (0.1-30 mM) on serotonin-pre-contracted human umbilical artery and the role of nitric oxide in these effects were analyzed. Diazoxide, isoproterenol and magnesium produced concentration-dependent relaxation of human umbilical artery precontracted with serotonin (10(-6) M). During cooling, the pIC(50) values and maximal responses to these agents were significantly lower than at 37 degrees C. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effects of temperature on diazoxide, isoproterenol and magnesium-induced relaxations. These results suggest that cooling-induced changes of diazoxide, isoproterenol, and magnesium sulphate in human umbilical artery are independent of nitric oxide.
Açıklama
Anahtar Kelimeler
cooling, diazoxide, isoproterenol, magnesium, nitric oxide, umbilical artery
Kaynak
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
131
Sayı
5
