Role of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Cooling

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dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorNurullahoğlu, Zahide Ülya
dc.contributor.authorKılıç, M.
dc.date.accessioned2020-03-26T18:16:00Z
dc.date.available2020-03-26T18:16:00Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the effects of cooling (to 28 degrees C) on the vasodilatation induced by diazoxide (10(-9)-3x 10(-4) M), isoproterenol (10(-9)-3x 10(-4) M) and magnesium sulphate (0.1-30 mM) on serotonin-pre-contracted human umbilical artery and the role of nitric oxide in these effects were analyzed. Diazoxide, isoproterenol and magnesium produced concentration-dependent relaxation of human umbilical artery precontracted with serotonin (10(-6) M). During cooling, the pIC(50) values and maximal responses to these agents were significantly lower than at 37 degrees C. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effects of temperature on diazoxide, isoproterenol and magnesium-induced relaxations. These results suggest that cooling-induced changes of diazoxide, isoproterenol, and magnesium sulphate in human umbilical artery are independent of nitric oxide.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipWe wish to thank Dr. Faruk Sukan, Obstetrics and Pediatry Hospital for kindly providing the umbilical cords for the study. This study is supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.doi10.1248/yakushi.131.661en_US
dc.identifier.endpage667en_US
dc.identifier.issn0031-6903en_US
dc.identifier.issue5en_US
dc.identifier.pmid21532262en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://dx.doi.org/10.1248/yakushi.131.661
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26791
dc.identifier.volume131en_US
dc.identifier.wosWOS:000290188300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPHARMACEUTICAL SOC JAPANen_US
dc.relation.ispartofYAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPANen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoolingen_US
dc.subjectdiazoxideen_US
dc.subjectisoproterenolen_US
dc.subjectmagnesiumen_US
dc.subjectnitric oxideen_US
dc.subjectumbilical arteryen_US
dc.titleRole of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Coolingen_US
dc.typeArticleen_US

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