The Effects of Alpha Lipoic Acid on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in the Rabbit

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dc.contributor.authorErdi, Mehmet Fatih
dc.contributor.authorGuney, Onder
dc.contributor.authorKiyici, Aysel
dc.contributor.authorEsen, Hasan
dc.date.accessioned2020-03-26T18:16:47Z
dc.date.available2020-03-26T18:16:47Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIM: The aim of this study is to determine the effects of a strong dithiol antioxidant, alpha lipoic acid (ALA) on cerebral vasospasm following subarachnoid hemorrhage in a rabbit model. MATERIAL and METHODS: Twenty-one New Zealand white rabbits were assigned to one of three groups: group 1 (control), group 2 (SAH only), group 3 (SAH+ALA). ALA was administered (100 mg/kg/day, single dose, intraperitoneally). The rabbits were sacrificed 72 hours after SAH. The basilar artery lumen areas, arterial wall thickness and endothelial apoptosis in a cross section of basilar artery were measured in all groups. The tissue MDA, SOD, GSH-Px levels were also determined. RESULTS: The elevated tissue MDA levels after SAH were significantly reduced by ALA treatment. The reduced tissue SOD and GSH-Px levels after SAH were also elevated by ALA treatment. In the treatment group the average wall thickness and the mean percentages of apoptotic cells (apoptotic index) were reduced and the average cross-sectional areas of the basilar artery were increased statistically significantly. CONCLUSION: ALA treatment attenuates the severity of cerebral vasospasm by its strong antioxidant, antivasospastic and antiapoptotic properties. ALA may potentially serve as agents in the prevention of cerebral vasospasm after SAH.en_US
dc.identifier.doi10.5137/1019-5149.JTN.4431-11.1en_US
dc.identifier.endpage533en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue4en_US
dc.identifier.pmid22194111en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage527en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.4431-11.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26927
dc.identifier.volume21en_US
dc.identifier.wosWOS:000297229200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectSubarachnoid hemorrhageen_US
dc.subjectRabbiten_US
dc.subjectVasospasmen_US
dc.titleThe Effects of Alpha Lipoic Acid on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage in the Rabbiten_US
dc.typeArticleen_US

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