Warming and Response to Contractile Agents in Calf Cardiac Vein: Role of the Nitric Oxide
Yükleniyor...
Dosyalar
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BLACKWELL PUBLISHING LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of warming on the response to various contractile agents of calf cardiac vein were studied using 2.5-mm long cylindrical segments. Concentration-response curves for carbachol (10(-9)-3 x 10(-4) M), 5-hydroxytryptamine (5-HT; 10(-8)-3 x 10(-3)), potassium chloride (KCl; 10(-4)-5 x 10(-2) m) and calcium chloride (CaCl2; 10(-4)-10(-2)) were isometrically recorded at 37 and 41degreesC (warming). During warming the sensitivity, but not the maximal response, of carbachol 5-HT, KCl, and CaCl2 was significantly higher than at 37degreesC. Warming to 41degreesC after treatment with N-G-nitro-L arginine methyl esther (10(-5) m) did not modify the effect of warming. These results suggest that nitric oxide seems to have no role in the warming-induced responses in calf cardiac vein.
Açıklama
Anahtar Kelimeler
Cardiac vein, Contractions, Nitric Oxide, Warming
Kaynak
Fundamental & Clinical Pharmacology
WoS Q DeÄŸeri
Q3
Scopus Q DeÄŸeri
Q2
Cilt
17
Sayı
1
Künye
Atalik, K. E., Sahin, A. S., Ulusoy, H. B., Dogan, N., (2003). Warming and Response to Contractile Agents in Calf Cardiac Vein: Role of the Nitric Oxide. Fundamental & Clinical Pharmacology, 77(1), 77-82. DOÄ°: 10.1046/j.1472-8206.2003.00142.x
