HLA-B27 Subtypes ın Turkish Patients with Ankylosing Spondylitis and Healthy Controls

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dc.contributor.authorAcar, Muradiye
dc.contributor.authorCora, Tulin
dc.contributor.authorTunc, Recep
dc.contributor.authorAcar, Hasan
dc.date.accessioned2020-03-26T18:30:41Z
dc.date.available2020-03-26T18:30:41Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine human leukocyte antigen (HLA)-B27 subtypes frequency in ankylosing spondylitis (AS) and related spondyloartropathy (SpA) patients. Therefore, we investigated the differences in HLA-B27 subtypes between HLA-B27-positive patients and controls. Sixty six patients were included in this study (51 AS and 15 SpA). Thirty-five individuals were diagnosed with leukemia or chronic renal failure, and their donors without any rheumatological problem (no SpA history) were selected as the control group. HLA-B27 subtyping was performed by PCR-SSP (polymerase chain reaction with sequence-specific primer) method in serologically HLA-B27-positive 46 AS patients, 9 SpA patients and control group. When the frequency of HLA-B27 was 4.5% in Turkish population, this frequency was 90.2% in AS patients. Four different HLA-B27 subtypes found in AS patients were B*2705 (65.2%), B*2702 (26.1%), B*2704 (6.5%) and B*2707 (2.2%). In SpA patients, B*2705 and B*2702 found in equal frequency. Five B27 alleles were identified in our control group: B*2705 (54.3%), B*2702 (31.4) %, B*2703 (2.9%), B*2704 (2.9%) and B*2702/B*2705 (8.5%). Both in the patient group and in the control group, we also observed B*2705 as most frequent allele, and B*2702 was second common allele. Our results show that the frequency of HLA-B27 subtypes is not significantly different between patients and controls (P > 0.10).en_US
dc.identifier.citationAcar, M., Cora, T., Tunc, R., Acar, H., (2012). HLA-B27 Subtypes ın Turkish Patients with Ankylosing Spondylitis and Healthy Controls. Rheumatology International, (32), 3103-3105. Doi: 10.1007/s00296-011-2099-0
dc.identifier.doi10.1007/s00296-011-2099-0en_US
dc.identifier.endpage3105en_US
dc.identifier.issn0172-8172en_US
dc.identifier.issn1437-160Xen_US
dc.identifier.pmid21927904en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3103en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00296-011-2099-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28113
dc.identifier.volume32en_US
dc.identifier.wosWOS:000309254000020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorTunc, Recep
dc.institutionauthorCora, Tulin
dc.institutionauthorAcar, Muradiye
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHLA-B27 subtypesen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectTurkish populationen_US
dc.titleHLA-B27 Subtypes ın Turkish Patients with Ankylosing Spondylitis and Healthy Controlsen_US
dc.typeArticleen_US

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